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Böbrek Allogreftlerinde Verici Kaynaklı Hücrelerin Varlığı

The Presence of Recipient-Derived Renal Cells in Kidney Allografts

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 20
DOI: 
10.5262/tndt.2011.1003.05

Key Words:

Keywords (Original Language):

Author NameUniversity of Author
Abstract (2. Language): 
OBJECTIVES: There are confl icting data regarding the insulin resistance in autosomal dominant polycystic kidney disease(ADPKD) patients. We investigated the relationship between insulin resistance and anthropometric measurements in patients with ADPKD. MATERIAL and METHODS: Thirty-six female and twenty-eight male patients were included. HOMA-IR formula was used for determination of insulin resistance. Body mass index(BMI); neck, midarm, waist and hip circumferences; and skin fold thicknesses (SFT) at biceps triceps, subscapular, umbilical and suprailiac regions were recorded, and total body fat ratios were calculated. Patients were divided into four groups according to their creatinine clearance. RESULTS: Twenty-seven patients (42.18%) had insulin resistance. HbA1c, HOMA-IR, insulin and glucose levels, anthropometric measurements and total body fat ratios were not statistically different among the groups. Total body fat was signifi cantly correlated with HOMA-IR. The best predictor of glucose intolerance was found to be subscapular SFT. BMIs were not different in patients grouped according to their GFR. But, insulin resistance was higher in the group with BMI>25. CONCLUSION: A direct relationship between ADPKD and insulin resistance was not been shown in the study. The relationship between anthropometric measurements and insulin resistance in ADPKD patients is similar to the general population.
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Abstract (Original Language): 
AMAÇ: Otozomal dominant polikistik böbrek hastalığı (ODPKBH) olan hastalarda insülin direncine dair çelişkili veriler vardır. ODPKBH olan vakalarda insülin direnci ile antropometrik ölçümler arasındaki ilişkiyi araştırdık. GEREÇ ve YÖNTEMLER: Otuz altı kadın ve yirmi sekiz erkek hasta dahil edildi. İnsülin direncinin tespiti için HOMA-IR formülü kullanıldı. Vücut kütle indeksi (VKİ); boyun, orta kol, bel ve kalça çevreleri ile biseps, triseps, skapula altı, umbilikal ve suprailiak bölgelerdeki deri kıvrım kalınlıkları (DKK) kaydedildi, ve toplam vücut yağ oranları hesaplandı. Hastalar kreatinin klirensi değerlerine göre dört gruba ayrıldı. BULGULAR: Yirmi yedi hastanın (%42.18) insülin direnci vardı. HbA1c, HOMA-IR, insülin ve glukoz düzeyleri, antropometrik ölçümler ve toplam yağ oranları gruplar arasında istatistiksel olarak farklı değildi. Toplam yağ oranı HOMA-IR ile anlamlı derecede korele bulundu. Glukoz entoleransının en iyi belirleyicisi skapula altı DKK idi. Hastalar GFR değerlerine göre sınıfl andırıldığında VKİ değerleri farksızdı. Fakat, insülin direnci VKİ 25’in üzerinde olan grupta daha yüksekti. SONUÇ: Bu çalışmada, ODPKBH ve insülin direnci arasında direkt bir ilişki gösterilmemiştir. Antropometrik ölçümler ile insülin direnci arasındaki ilişki ODPKBH olan hastalarda genel popülasyondakine benzerdir.
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241-247
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REFERENCES

References: 

1. Gabow PA: Autosomal dominant polycystic kidney disease. N Engl
J Med 1993; 329: 332-342
2. Ecder T: Otozomal dominant polikistik böbrek hastalığında
hipertansiyon ve kardiyovasküler sorunlar. Turk Neph Dial Transpl
2007; 16: 22-26
3. Crutchlow MF, Robinson B, Papachen B, Wimmer N, Cucchiara AJ,
Cohen D, Townsend R: Validation of steady state insulin sensitivity
indices in chronic kidney disease. Diabetes Care 2007; 30: 1813-1818
4. Chen J, Muntner P, Hamm LL, Fonseca V, Batuman V, Whelton
PK, He J: Insulin resistance and risk of chronic kidney disease in
nondiabetic US adults. J Am Soc Nephrol 2003; 14: 469-477
5. Chen J, Muntner P, Hamm LL, Jones DW, Batuman V, Fonseca V,
Whelton PK, He J: The metabolic syndrome and chronic kidney
disease in US adults. Ann Intern Med 2004; 140: 167-174
6. Kurella M, Lo JC, Chertow GM: Metabolic syndrome and the risk
for chronic kidney disease among nondiabetic adults. J Am Soc
Nephrol 2005; 16: 2134-2140
7. Lasser NL, Grandits G, Caggiula AW, Cutler JA, Grimm RH Jr,
Kuller LH, Sherwin RW, Stamler J: Effects of antihypertensive
therapy on plasma lipids and lipoproteins in the Multiple Risk
Factor Intervention Trial. Am J Med 1984; 76: 52-65
8. Navalesi R, Pilo A, Lenzi S, Donato L: Insulin metabolism in
chronic uremia and in the anephric state: Effect of the dialytic
treatment. J Clin Endocrinol Metab 1975; 40(1): 70-85
9. Westervelt FB: Insulin effects in uremia. J Lab Clin Med 1969;
74(1): 79-84
10. Vareesanggthipp K, Tong P, Wilkinson R, Thomas TH: Insulin
resistance in adult polycystic kidney disease. Kidney Int 1997; 52:
503-508
11. Hjelmeaeth J, Hartmann A: Insulin resistance in patients with
adult polycystic kidney disease. Nephrol Dial Transplant 1999; 14:
2521-2522
12. Vareesangthip K, Tong P, Wilkinson R, Trevor H T: Insulin
resistance in adult polycystic kidney disease. Kidney International
1997; 52: 503-508
13. Tong P, Thomas T, Berrish T, Humphriss D, Barriocanal L, Stewart
M, Walker M, Wilkinson R, Alberti KG: Cell membrane dynamics
and insulin resistance in non-insulin-dependent diabetes mellitus.
Lancet 1995; 345: 357-358
247
Kazancıoğlu R et al : Insulin Resistance and Antropometric Measurements in
Autosomal Dominant Polycystic Kidney Disease
Türk Nefroloji Diyaliz ve Transplantasyon Dergisi
Turkish Nephrology, Dialysis and Transplantation Journal
Turk Neph Dial Transpl 2011; 20 (3): 241-247
14. Lim SC, Tan BY, Chew SK, Tan CE: The relationship between
insulin resistance and cardiovascular risk factors in overweight/
obese non-diabetic Asian adults: The 1992 Singapore National
Health Survey. Int J Obes Relat Metab Disord 2002; 26: 1511-1516
15. Kahn CR, Weir GC, King GL, Jacobson AM, Moses AC, Smith
RJ: Joslin’s Diabetes Mellitus, in Hawkins M Rossetti L: Insulin
resistance and its role in the pathogenesis of type II diabetes.
Philadelphia PA: Lippincott Williams and Wilkins, 2005; 425-448
16. Turkmen K, Tufan F, Alpay N, Kasıkcıoglu E, Ofl az H, Ecder SA,
Ecder T: Insulin resistance and coronary fl ow velocity reserve in
patients with autosomal dominant polycystic kidney disease. Intern
Med J 2010;
17. De Fronzo RA, Tobin JD, Andres R: Glucose clamp technique: A
method for quantifying insulin secretion and resistance. Am J Phsiol
1979; 237: 214-223
18. Bonora E, Targher G, Alberiche M, Bonadonna RC, Saggiani F,
Zenere MB, Monauni T, Muggeo M: Homeostasis model assessment
closely mirrors the glucose clamp technique in the assessment of
insulin sensitivity. Diabetes Care 2000; 23: 57-63
19. Kopelman PG, Stock MJ: Clinical obesity: Oxford: Blackwell
Science, 1998
20. Ravine D, Gibson RN, Walker RG, Sheffi eld LJ, Kincaid-Smith P,
Danks DM: Evaluation of ultrasonographic diagnostic criteria for
autosomal dominant polycystic kidney disease. Lancet 1994; 343:
824-827
21. Durnin JV, Womersly J: Body fat assessed from total body density
and its estimation from skinfold thickness: Measurements on 481
men and women aged from 16 to 72 years. Br J Nutr 1974; 32: 77-97
22. Siri W: Body composition from fl uid spaces and density: Analysis
of methods. In: Brozek J, Hanschel A (Eds). Techniques for
measuring body composition. Washington, DC: National Academy
of Sciences, 1961; 223-244
23. Pietrzak-Nowacka M, Rózanski J, Safranow K, Kedzierska K,
Dutkiewicz G, Ciechanowski K: Autosomal dominant polycystic
kidney disease reduces the risk of diabetes mellitus. Arch Med Res
2006; 37: 360-364
24. Fliser D, Pacini G, Engelleiter R, Kautzky-Willer A, Prager R,
Franek E, Ritz E: Insulin resistance and hyperinsulinemia are
already present in patients with incipient renal disease. Kidney Int
1998; 53: 1343-1347
25. De Mattos AM, Olyaei AJ, Prather JC, Golconda MS, Barry JM,
Norman DJ: Autosomal-dominant polycystic kidney disease as
a risk factor for diabetes mellitus following renal transplantation.
Kidney Int 2005; 67: 714-720
26. Pietrzak-Nowacka M, Safranow K, Rózański J, Debska-Slizień
A, Domański L, Dziewanowski K, Glyda M, Jnkowska M, Nocen
M, Pabisiak K, Rutkowski B, Wisniewska M, Ciechanowski
K: Autosomal dominant polycystic kidney disease is not a risk
factor for post-transplant diabetes mellitus. Matched-pair design
multicenter study. Arch Med Res 2008; 39: 312-319
27. Onat A, Sansoy V, Uyarel H, Keleş İ, Hergenç G: HDL-cholesterol
levels, environmental factors and metabolic syndrome criteria in
Turkish population. Türk Kardiyol Dern 2004; 32: 273-278
28. Clinical Guidelines on the Identifi cation, Evaluation and Treatment
of Overweight and Obesity in Adults-The evidence Report. National
Institutes of health. Obes Res 1998; 6: 51-209
29. Hatemi H, Turan N, Arik N, Yumuk VD: Results of Turkey obesity
and hypertension screening. Endokrinolojide Yönelişler 2002;
11(1): 1-16
30. Khaodhiar L, Blackburn GL: Results of Expert Meetings: Obesity
and Cardiovascular Disease: Obesity assessment. Am Heart J 2001;
142: 1095-1101
31. Calle EE, Thun MJ, Petrelli JM, Rodriguez C, Heath CW Jr: Bodymass
index and mortality in a prospective cohort of U.S. adults.
N Engl J Med 1999; 341: 1097-1105
32. Desrpres JP: Dyslipidemia and obesity. Bailliere’s Clin Endocrinol
Metab 1994; 8: 629-660
33. Pouliot MC, Després JP, Lemieux S, Moorjani S, Bouchard C,
Tremblay A, Nadeau A, Lupien PJ: Waist circumference and
abdominal sagittal diameter: Best simple anthropometric indices
of abdominal visceral adipose tissue accumulation and related
cardiovascular risk in men and women. Am J Cardiol 1994; 73:
460-468
34. Kissebah AH, Videlingum N, Murray R, Evans DJ, Hartz AJ,
Kalkhoff RK, Adams PW: Relation of body fat distribution to
metabolic complications of obesity. J Clin Endocrinol Metab 1982;
54: 254-260
35. Chan DC, Watts GF, Barrett PH, Burke V: Waist circumference,
waist-to-hip ratio and body mass index as predictors of adipose
tissue compartments in men. QJM 2003; 96: 441-447
36. Hargreaves AD, Logan RL, Elton RA, Buchanan KD, Oliver MF,
Riemersma RA: Glucose tolerance, plasma insulin, HDL cholesterol
and obesity: 12-year follow-up and development of coronary heart
disease in Edinburgh men. Atherosclerosis 1992; 94: 61-69
37. Misra A, Madhavan M, Vikram NK, Pandey RM, Dhingra V,
Luthra K: Simple anthropometric measures identify fasting
hyperinsulinemia and clustering of cardiovascular risk factors in
Asian Indian adolescents. Metabolism 2006; 55: 1569-1573
38. Owa JA, Adejuyigbe O: Fat mass, fat mass percentage, body mass
index and mid-upper arm circumference in a healthy population of
Nigerian children. J Trop Pediatr 1997; 43: 13-19
39. Himes JH, Roche AF, Webb P: Fat areas as estimates of total body
fat. Am J Clin Nutr 1980; 33: 2093-2100
40. Gabow PA, Johnson AM, Kaehny WD, Kimberling WJ, Lezotte
DC, Duley IT, Jones RH: Factors affecting the progression of renal
disease in autosomal polycystic kidney disease. Kidney Int 1992;
41: 1311-1319
41. Geberth S, Ritz E, Zeier M, Stier E: Anticipation of age at renal
death in autosomal dominant polycystic kidney disease. Nephrol
Dial Transplant 1995; 10: 1603-1606

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