KSENOTRANSPLANTASYONUN İMMÜNOLOJİK YÖNÜ

Aytül Sin; Ali Kokuludağ; Tomris Kabakçı

IMMUNOLOGIC SIDES OF XENOTRANSPLANTATION

Journal Name:

Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

1995

Key Words:

Keywords (Original Language):

Author Name	University of Author	Faculty of Author
Aytül Sin	Ege Üniversitesi	Tıp Fakültesi
Ali Kokuludağ	Ege Üniversitesi	Tıp Fakültesi
Tomris Kabakçı	Ege Üniversitesi	Tıp Fakültesi

Abstract (2. Language):

Xenotransplantation is viewed as the most promising way to overcome the problems of shortage of donor organ. It can be exploited from rapidly expanding capabilities in genetic engineeringfor xenotransplan-tation. The major immunological hurdle to tissue or organ transplantations between phylogenetically-dis-tant individuals is humoral immunity. In particular, immonupathologic effecs mediated by the reaction of natural antibodies and complement of recipient with graft endothelium in the donor organ cause xenograft rejection. Nevertheless, the phenomenon called "accomodation" that will occur immunologically may allow long survival of xenografts. In this review, immunolo-gic hurdles to xenotransplantation and studies for overcoming the consequences of these will be discus¬sed.

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Abstract (Original Language):

Ksenotransplantasyon, donör organ bulma konusundaki sorunları çözümleyecek en umut verici yöntem olarak görünmektedir. Ayrıca ksenotransplantas-yonda, giderek ilerleyen genetik mühendisliğinin im¬kanlarından da yararlanılabilir. Ancak filogenetik olarak farklı bireyler arasında yapılan doku yada or¬gan nakillerine en büyük engel humoral immün sis¬temden gelmektedir, özellikle doğal antikorlar ve kompleman sistemi aracılığı ile graft endoteli üzerinde oluşan immünopatolojik etkiler ksenotransplant rejeksiyonuna neden olur. Bununla birlikte; immüno¬lojik olarak oluşacak "akomodasyon" olgusu, ksenog-raftların yaşam sürelerini uzatabilir. Bu yazıda, ksenotransplantasyon için immünolojik engeller ve bun¬ların etkilerini ortadan kaldırmaya yönelik çalışma¬lar tartışılacaktır.

FULL TEXT (PDF):

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Turkish

REFERENCES

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KSENOTRANSPLANTASYONUN İMMÜNOLOJİK YÖNÜ

Journal Name:

Publication Year:

Key Words:

Keywords (Original Language):

immünoloji