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RENAL OSTEODÎSTROFÎ ÜZERİNE FOSFOR BAĞLAYICILAR VE KALSÎTRÎOLÜN ETKÎSÎ

THE EFFECT OF PHOSPHATE BINDERS AND CALCITRIOL ON RENAL OSTEODISTROPHY

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 1995

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Renal osteodistrophy occurs due to the factors such as secondary hyperparathyroidism, active vita¬min D deficiency, aluminium retention and heparin used during hemodialysis. While renal osteodistrophy was observed in 40 % of cases at chronic hemodialy-sis in the past, currently this ratio decreased owing to better control of serum phosphate, proper choice of dialysate calcium and administration of prophylactic vitamin D metabolites. In the present study, the effects of different phosphate binders and calcitriol on renal osteodistrophy were investigated. No changes were observed in trabecular bone mineral density (tKMD) at groups who received aluminium hydroxide and cal¬cium carbonate therapy for the first 3 months and af¬ter the second 3 months, during which combination of calcium carbonate + calcitriol were administred to the same group, significantly increased tKMD were observed (p<0.05). Consequently, it may be said that changes in tKMD are observed with combined treat¬ments lasting 3 months despite the suggestions made as too longer periods of treatment in literature.
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Abstract (Original Language): 
Renal Osteodistrofi sekonder hiperparatiroidizm, aktif vitamin D eksikliği, alüminyum birikimi ve diyaliz sırasında kullanılan heparin gibi faktörlere bağlı oluşur. Eskiden kronik hemodiyaliz programındaki vakaların % 40'ında Renal Osteodistrofi görülürken günümüzde serum fosforunun daha iyi kontrol edilme¬si, diyalizat kalsiyumunun daha iyi seçilmesi ve profi-laktik vitamin D metabolitlerinin kullanılması bu ora¬nı oldukça azaltmıştır. Bu çalışmada farklı fosfor bağlayıcılar ile kalsitriolün renal osteodistrofi üzeri¬ne etkileri araştırıldı. 3 aylık alüminyum hidroksit ve kalsiyum karbonat tedavisi alan gruplarda trabeküler kemik mineral dansitesinde (tKMD) değişiklik olma¬dığı, kalsiyum karbonat + kalsitriol kombinasyonu¬nun uygulandığı ikinci üç aylık dönemde ise tKMD'de anlamlı artış olduğu görüldü (p<0.05). Sonuç olarak, literatürde daha uzun süreler önerilmesine rağmen tKMD'deki değişikliklerin üç aylık kombine tedaviler ile de görülebileceği söylenebilir.
FULL TEXT (PDF): 
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  • 2
86-90
  • Turkish

REFERENCES

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