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CAPD TEDAVİSİ UYGULANAN HASTALARDA DÎYALÎZ YETERLİLİĞİ VE BESLENME DURUMU GÖSTERGELERİNİN ÜREMİK SEMPTOMLARLA İLİŞKİSİ

THE RELATIONSHIP BETWEEN INDICES OF DIALYSIS ADEQUACY AND NUTRITIONAL STATUS AND UREMIC SYMPTOMS IN CAPD PATIENTS

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Abstract (2. Language): 
We examined the relationship between quantitative indices of dialysis adequacy and nutritional status and patient-reported uremic symptomss in 20 CAPD patients. The Kt/Vurea, weekly total creatinine clea¬rance (TCC), residual renal function (RRF), dialysis index (DI), normalized protein catabolic rate (NPCR) and serum albumin levels (SA) were calculated as in¬dices of dialysis adequacy and nutritional status. The checklist consisted of 7 uremic symptoms, each scored from 0-3. The total symptom score was negatively correlated with Kt/Vurea (p<0.01), weekly TCC (p=0.01), DI (p<0.05), NPCR (p=0.001) and SA (p<0.0001). In patients whose total symptom score was higher than 7, Kt/Vurea (p<0.001), weekly TCC (p<0.01), RRF (p< 0.01), DI (p<0.05), NPCR (p<0.0001) and SA (p< 0.0001) were significantly lo¬wer than those in others. CAPD was intensified in pa¬tients considered to be inadequately dialyzed accor¬ding to kinetic parameters with resolution of the ure-mic symptoms. In conclusion, dialysis dose prescripti¬on according to kinetic parameters is very useful in preventing uremic symptoms inpatients with CAPD.
Abstract (Original Language): 
CAPD tedavisi uygulanan 20 hastada diyaliz ve beslenme yeterliliğinin kantitatif göstergeleri ile hastanın belirttiği üremik semptomlar arasındaki ilişki incelendi. Diyaliz ve beslenme yeterliliği göstergeleri olarak Kt/Vüre, haftalık total kreatinin klirens (TKK), rezidüel renal fonksiyon (RRF), diyaliz indeksi (Di), normalize protein katabolizma hızı (NPCR) ve serum albümin düzeyi (SA) hesaplandı. Ayrıca, 7 üremik semptomdan oluşan listeye 0-3 arasında değişen pu¬an verilerek, toplam semptom skoru belirlendi. Semp¬tom skoru ile Kt/Vüre (p<0.01), haftalık TKK (p=0.01), Di (p<0.05), NPCR (p=0.001) ve SA (p<0.0001) arasında anlamlı negatif korelasyonlar saptandı. Yine, semptom skoru 7'nin üzerinde olan hastalarda ortalama Kt/Vüre (p<0.001), haftalık TKK (p<0.01), RRF (p<0.01), Di (p<0.05), NPCR (p<0.0001) ve S A (p<0.0001) değerleri anlamlı ola¬rak düşük bulundu. Kinetik parametrelere göre yeter¬siz diyaliz oldukları düşünülen hastalarda, diyaliz do¬zu arttırımı üremik semptomların gerilemesine yol açtı. Sonuç olarak, CAPD tedavisi uygulanan hasta¬larda kinetik parametrelere göre diyaliz dozu tayini, hastaları üremik semptomlardan korumada oldukça, paradidir.
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