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HEMODİYALİZ HASTALARINDA TOTAL LENFOSİT, CD4, CD8 VE CD4/CD8 ORANINA DEĞİŞİK FAKTÖRLERİN ETKİLERİ

THE EFFECTS OF VARIOUS FACTORS ON TOTAL LYMPHOCYTE, CD4, CD8 LYMPHOCYTE AND CD4/CD8 RATIO IN HEMODIALYSIS PATIENTS

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 1995

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
is shown that rHu-EPO and calcitriol treatment and type of dialysis membrane effect total lymphocyte CD4, CD8 lymphocyte counts and CD4.CD8 ratio in hemodialysis patients (HP). The aim of this study was investigate the effect of different factors on these cell populations in hemodialysis patients. 10 healthy indi¬viduals and 36 HP were included in this study. Pati¬ents were dialysed 4 hours twice or three times weekly with polysulphone membrane. All patients were given calcitriol (0.25 microgram! day), calcium (2 gram/day) and other medications as required. Blood samples were taken before each dialysis session. Total lymphocytes count was performed using Technicon HI 873. CD4, CD8 lymphocytes was meusared by IF A. Data were analysed by minitab computer statis¬tic programs (t test, correlation tests). Total lymphocytes, CD4, CD8 lymphocytes and CD4, CD8 lymphocytes and CD4: CD8 ratio of IIP were those of the control group. There was no correlation between total lymphocytes, CD4, CD8 lymphocytes, CD4.CD8 ratio and age, sex, use of rHu-EPO, weight, liver function, time on dialysis and DIIEA-S in HP. Total lymphocytes, CD4, CD8 lymphocytes and CD4.CD8 ratios were high in HP with serum creatinine levels lower than 7 mg/dl. Although this increase was not significant. Increase in CD8 and decrease in CD4.CD8 ratio were significant in anti HCVpositive HP. Key
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Abstract (Original Language): 
Total lenfosit, CD4, CD8 lenfosit, CD4.CD8 oranını, hemodiyaliz hastalarında diyaliz membranı tipi, eritropoieün ve kalsitriol kullanımının etkilediği bildirilmektedir. Bu araştırmada 10 sağlıklı gönüllü ve 36 hemodiyaliz hastası dahil edildi. Hastalar haftada 2 veya 3 kez 4 saat süre ile polisulfon membranlı diyalize giriyorlardı. Tüm hastalara 0.25 \xglgün kalsit-riol, 2 g/gün kalsiyum ve diğer rutin kronik böbrek yetmezliği ilaçları veriliyordu. Kan örnekleri diyaliz öncesi alındı. Total lenfosit sayımı Technicon Hl 873 ile yapıldı. CD4 ve CD8 immunfluoresan tekniği ile sayıldı. Sonuçlar AppsIMinitab bilgisayar istatistik programı ile değerlendirildi. Hemodiyaliz hastaların¬da total lenfosit, CD4, CD8 ve CD4:CD8 oranı kont¬rol grubuna göre daha düşüktü (p<0.01). Total lenfosit, CD4, CD8 ve CD4.CD8 oranı ile yaş, cinsiyet, eritropoieün kullanımı, ağırlık, karaciğer fonksiyon testleri, diyaliz süresi, kortizol, total testosteron ve DHEA-S arasında anlamlı korelasyon yoktu. Anti-HCV pozitif hastalarda anti-HCV negatif hastalara göre istatistiki olarak CD8 yüksek, CD4:CD8 oranı ise düşüktü (p<0.01).
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  • 3
146-150
  • Turkish

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