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KOMPANSE KRONİK BÖBREK YETMEZLİKLİ HASTALARDA SERUM LIPOPROTEIN (a) DÜZEYİ

SERUM LIPOPROTEIN (a) LEVELS IN PATIENTS WITH CHRONIC RENAL FAILURE NOT RECEIVING DIALYSIS

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 1996

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Lipid abnormalities contribute to the increase in cardiovascular morbidity and mortality in chronic re¬nal failure (CFR) patients with or without dialysis. Li-poprotein (a) and, a unique lipoprotein has been shown to be an independent risk factor for the deve¬lopment of cardiovascular disease in general popula¬tion. This study was planned to assess the serum le¬vels of Lp(a) in predialytic CFR patients. In this study, lipid andLp(a) levels were measured in 27pre-dialytic CFR patients consisting of 14 males, 13 fema¬les and in age-and sex-matched thirty one controls. In CFR patients, HDL chol esterol level were lower and apo B were higher as compared to the control group. Moreover, Lp(a) was found to be prominently higher in CFR patients than in controls. There was a signifi¬cant positive correlation between Lp(a) levels and the amount of proteinuria. Our data suggest that increa¬sed Lp(a) level along with low level of HDL choleste¬rol and high level of Apo B may pose a significant risk factor for atherosclerotic cardiovascular disease in CFR patients.
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Abstract (Original Language): 
KBY'li hastalarda sık rastlanan lipoprotein metabolizması anormallikleri ve hiperlipidemi, ateroskle-rotik kalb ve damar hastalığı riskini artırmaktadır. Çalışmamızda, 27 KBY'li hastada lipoprotein (a) ve diğer apoplipoproteinlerin düzeyleri değerlendirilmiş ve yaş ve cins uyumlu 31 kişiden oluşan kontrol grubu ile karşılaştırılmıştır. KBY'li hastalarda HDL-Kolesterol düzeyi düşük, apoprotein B ve lipoprotein (a) düzeyleri yüksek bulunmuştur. İdrar ile protein kaybı ve Lp (a) arasında anlamlı bir ilişki saptanmış¬tır. Diğer apoplipoprotein anormallikleri ile birlikte, bağımsız bir risk faktörü olan serum Lp (a) düzeyin¬deki belirgin yükselme, KBY'li hastalarda aterosklero-tik olayın hızlanmasına katkıda bulunabilir.
FULL TEXT (PDF): 
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  • 1
11-15
  • Turkish

REFERENCES

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