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MINIMAL LEZYON HASTALıĞıNDA ENFEKSİYONLARIN VE STEROID TEDAVİSİNİN IG G ALT GRUPLARı İLE İLİŞKİSİ

THE RELATIONSHIP OF IgG SUBCLASSES AND OF STEROID THERAPY AND INFECTIONS IN MINIMAL CHANGE DISEASE

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 1997

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Relapses are important problems in minimal chan¬ge disease which accounts most of the cases in child¬hood nephrotic syndrome. Infection is the most im¬portant complication that determines mortality and morbidity. Because of defects in humoral immune system, patients are predispose to infections in neph-rotic syndrome. In this study, serum levels of IgG and its subclasses were studied to evaluate the relations¬hips between the nephrotic syndrome and infection on 17 children with nephrotic syndrome (24-96 months of age) and 10 healty children (27-84 months of age). At the end of this study, serum levels of IgG and its subclasses were found to be lower in active disease group than the contol group. However, these values were lowest for the infection group. Although it was observed that these values increased with steroid tre¬atment , they did not reach to normal levels. The pa¬rameters in the remission were not differentfrom the parameters in control subjects.
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Abstract (Original Language): 
Çocukluk çağı nefrotik sendromlannın büyük bir kısmını oluşturan minimal lezyon hastalığında re-lapslar önemli bir sorun oluştururken, mortalite ve morbiditeyi belirleyen en önemli komplikasyonu en¬feksiyonlar teşkil etmektedir. Nefrotik sendrotnda en¬feksiyon gelişme nedenlerinden biri olarak humoral immun sistemdeki defektler gösterilmektedir. Nefrotik sendromla enfeksiyon arasındaki ilişkiyi saptamak amacıyla bu çalışmada Erciyes Üniversitesi Tıp Fa¬kültesi Pediatrik Nefroloji Bilim Dalında minimal lez-yon hastalığı tanısı alan yaşlan 24 ile 96 ay arasında değişen 17 çocukta (dokuz erkek, sekiz kız) ve yaşlan 27 ile 84 ay arasında değişen 10 sağlıklı çocukta (altı erkek, dört kız) Ig GvelgG alt grupları ölçüldü. Çalışma sonunda aktif hastalık grubunda ortalama serum Ig G ve Ig G alt gruplarının normale göre dü¬şük olduğu, bu düşüklüğün enjeksiyonlu grupta daha belirgin olduğu saptandı. Steroid tedavisi ile bu de¬ğerlerin yükseldiği fakat normale ulaşmadığı gözlen¬di. Remisyondaki olgularda ise bu verilerin kontrol grubu ile farklı olmadığı belirlendi.
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  • 1-2
26-30
  • Turkish

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