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MINIMAL LEZYON NEFROTIK SENDROMDA APOLIPOPROTEIN DEĞIŞIKLIKLERI

VARIATIONS OF SERUM APOLIPOPROTEIN LEVELS IN MINIMAL LESION NEPHROTIC SYNDROME

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 1998

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Variations in plasma lipids and lipoprotein levels were evaluated during the course of the nephrotic syndrome in 20 children (17 males, 3 females, aged 1,5-13 years). Of these ten were in relapse, ten were in remission. Results were compared to those obtained in a control population of 30 age-matched children. Serum apoprotein A1 (apo A1) levels were increased in children with relapsing nephrotic syndrome compared to controls (mean value of 131.863 mg/dl 5 vs. 11.220 mg/dl) but remained within the normal ranges (115-190 mg/dl). Of the patients in relapse apoprotein B (apo B) levels were measured as higher during the acute phase of the disease (284.7±93.4 mg/dl) and the lowest in remission (79.7±22.2 mg/dl) (p<0.05) compared with controls (92.1±27). The difference between apo B levels in remission and control groups was not statistically different.
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Abstract (Original Language): 
Minimal lezyon nefrotik sendromda (MLNS) relaps döneminde meydana gelen lipid ve apolipoprotein değişikliklerinin remisyon döneminde genellikle düzeldiği gösterilmiştir. Buprospektif'çalışmada MLNS'daplazma lipid ve lipoprotein değişiklikleri incelendi bu amaçla; yaşları 1.5¬13yıl arasında olan, 10'u remisyon, 10'u relaps döneminde toplam 20 MLNS'lu hastanın serum lipoprotein, apolipoprotein Al (apo Al) ve apolipoprotein B (apo B) düzeyleri ölçüldü. Aynı yaş grubunda 30 vakalık kontrol grubu ile karşılaştırıldı. Apo Al değerleri relapsda, remisyonda ve kontrol grubunda normal sınırlarda bulundu. Gruplar arasında anlamlı farklılık yoktu (p>0.05). Apo B değerleri relapsta (284.7'±93.4 mg/dl), remisyonda (79.7±22.2 mg/dl) ve kontrol grubunda (92.1±27mg/dl) olarak bulundu. Apo B değerleri açısından relaps ile remisyon ve relaps ile kontrol grubu arasında anlamlı farklılık varken (p<0.05), remisyon ile kontrol grubu arasında fark yoktu (p>0.05). MLNS'lu vakalarımızın rölaps döneminde Apo Al düzeyleri normal, Apo B düzeyleri yüksek olarak bulundu.
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  • Turkish

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