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KRONİK HEMODİYALİZ HASTALARINDA İŞİTME KAYBI VE ANTİOKSİDANLAR

HEARING LOSS AND ANTIOXIDANTS IN CHRONIC HEMODIALYSIS PATIENTS

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 1998

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
No satisfactory explanation has been made about chronic hemodialysis-induced hearing loss, yet. This study has been aimed to investigate whether there is a possible role of changes in antioxidant defense mechanisms in chronic hemodialysis-induced hearing loss. Sixty-six patients with chronic renal failure and 22 healthy volunteers were included in the study. The patients were divided into two groups as group 1 and 2 on the basis of the presence and absence of hearing loss, respectively. Forty-seven of 66 patients had hearing loss and nine-ten had not hearing loss. The controls were admitted as group 3. In all patients and controls audiologic tests were performed and the activities of antioxidants, and blood urea nitrogen, creatinin, uric acid, and albumin, and hearing threshold values were determined. This study showed that decreasing in antioxidant enzymes activities in chronic hemodialysis patients might have an important role in hearing loss.
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Abstract (Original Language): 
Kronik hemodiyalizin yol açtığı işitme kaybının etyolojisi konusunda henüz net bir sonuca ulaşılamamıştır. Bununla beraber, etyopatogenezde antioksidan savunma mekanizmalarındaki yetersizlik en popüler olarak suçlanan faktörlerdendir. Çalışmamız, antioksidan savunma mekanizmaları ile kronik hemodiyaliz (KHD) hastalarında ortaya çıkan işitme kaybı arasındaki ilişkiyi araştırma amacıyla yapıldı. Çalışmamıza KHD uygulanan 66 hasta ve kronik böbrek yetmezliği ve işitme kaybı şikayeti olmayan sağlıklı 22gönüllü dahil edildi. KHD uygulanan 66hastanın işitme kaybı saptanan 47'si Grup I'i ve işitme kaybı saptanmayan 19'u Grup 2 'yi oluştururken, 22 sağlıklı gönüllü Grup 3 'ü (kontrol grubu) oluşturdu. Çalışmamıza dahil edilenlerin tümünün odyolojik testleri, antioksidan enzimler (bakır-çinko süperoksit dizmutaz, katalaz ve glutatyon peroksidaz), kan üre azotu (BUN), kreatinin, ürik asit, hemoglobin ve albümin seviyeleri ölçüldü. Sonuç olarak, KHD hastalarında işitme kaybının antioksidan enzim aktivitelerindeki yetersizlikle ilişkili olabileceği kanısına varıldı
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97-101
  • Turkish

REFERENCES

References: 

1. Gatland D, Tucker B, Chalstrey S, Keene M, Baker L. Hearing loss in chronic renal failure-hearing threshold changes following haemodialysis. J R Soc Med 1991: 84:587-589.
2.
Dura
k İ, Akyol Ö, Başeşme E, Canbolat O. Ka\ııtcu M. Reduced erythrocyte defense mechanisms against free radical toxicity in patients with chronic renal failure. Nephron 1994; 66(l):76-80.
3. Bast A, Goris RJA. Oxidative stress. Biochemistry and human disease. Pharm Weekbl (Sci) 1989; 11(6): 199¬206.
4. Lowry OH, Rosenburg MY, Farr AL, et al. Protein measurement with the folin phenol reagent. J Biol
Chem 1951; 193:265-275.
5. Misra HP, Fridovich İ. Superoxide dismutase: Photochemical augmentation assay. Arch Biochem
Biophys 1977; 181:308-312.
6. Paynter Dİ. Changes in activity of the manganese superoxide dismutase enzyme in tissues of the rarat with changes in dietary manganese. J Nutr 1986; 110:437¬447.
7. Paglia DE, Valentine WN. Studies on the quantitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 1979; 70:158-168.
8;, Levander OA, DeLoach DP, Morris VC, et al. Platelet
glutathione peroxidase activity as a index of selenium
status in rats. J Nutr 1983; 113:55-63.
100
9. Aebi H. Catalase in vitro. Methods Enzymol 1984; 105:121-126.
10.
Özçağla
r HÜ, Dinç O, Fişenk F, Kılıçarslan S. Auditory
evoked potentials of the chronic renal failure patients before and after hemodialysis. Proceedings of the XV World Congress of ORL, Head and Neck Surgery 1993; 391-394.
11.
Gedikl
i O, Delibaş, N, Doğru H, et al. Kronik böbrek yetmezliğinde işitme kaybı ve antioksidanlar. KBB İhtisas Dergisi 1996; 3(2):594-599.
12.
Ömü
r M, Tezel İ, Hizalan İ. Kronik böbrek yetmezliğine bağlı işitme kayıpları ve bazı serum içerikleri ile ilişkisi. Türk ORL Derneği XVİ. Ulusal
Kongre Kitabı. Trabzon 1981, ss 141 -151.
13. Laitakari H. Vestibular disorders in medically managed chronic renal insufficiency. Acta Otolaryngol (Suppl) 1977;349:7-10.
14. Johnson DW, Mathog RH. Hearing function and chronic renal failure. Ann Otol 1976; 85:43-49.
15. Özen M, Sandıkçı O, Kadıoğlu A, Aguşoğlu N. Audiometry in chronic renal failure before and after
intermittent hemodialysis. EDTA 1974; 11:203-209.
16. Yassin A, Badry A, Fatt-Hi A. The relationship between electrolyte balance and cochlea disturbances in cases of
renal failure. J Laryngol Otol 1970; 84:429-436.
17. Ward J. Free radicals, antioxidants and preventive geriatrics. Australian Family Physician 1994;
23(7):1297-1301.
18. Paul JL, Man NK, Moatti N, Raichvarg D. Membrane phospholipid peroxidation in renal insufficiency and chronic hemodialysis. Nephrol 1991; 12:4-7.
19. Grinshtein İ, Lundina TA, Knubovets TL, Sibel'dina LA, Sedov KR. Free radical oxidation and tubular dysfunctions in patients with chronic kidney failure. Ter
Arkh 1991;63:62-65.
20. Haklar G, Yeğenağa İ, Yalçın AS. Evaluation of oxidant stress in chronic hemodialysis patients: use of
different parameters. Clin Chim Acta 1995; 234:109¬114.
21. Schimidtmann S, Muller M, von Baehr R, Precht K. Changes of antioxidative homeostasis in patients on chronic haemodialysis. Nephrol Dial Transp 1991; 6(Suppl3):71-74.
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