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DÎYALÎZ HASTALARINDA L-CARNÎTÎNE TEDAVİSİNİN ERİTROSİT OSMOTİK FRAJÎLÎTE ÜZERİNE ETKİLERİ

THE EFFECTS OF L-CARNITINE ON ERYTHROCYTES OSMOTIC FRAGILITY IN DIALYZED PATIENTS

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Abstract (2. Language): 
The aim of this study was to investigate the effects of L-Camitine (LC) treatment on erythrocyte osmotic fragility (EOF) that important cause of anemia in diyalized patients. 35 patients, with mean age 46.4±14 years on meintenance dialysis (17 heamodialysis-HD, 18 continious ambulatory periyonel dialysis-CAPD) and 44 healty individiuals with mean age 45±9 years were included to study. . Patients group received LC 2 g /day for 4 months then 20-25 mg/kg 3 days a week, for following 12 months. At initial, haemoglobin (Hb),haemotocrit (Hct) and Erythrocyte (Er) inpatients were lower (P<0.000) and EOF was higher (P<0.005) than those of the controls. Hb, Hct, Er were increased in 4 months then continued in further 12 months (P<0.0005, <0.005, <0.05). EOF decreased after 16 months and after discontinued LC, it showed to return the baseline value, but still was higher (<0.005) after 4 months discontinued LC . Free Carnitine increased after 16 months (P<0.000). Our findigs suggest that improvoment in anemia with LC treatment was due to decrasing effects of its on EOF.
Abstract (Original Language): 
Çalışmamızda, 17Hemodiyaliz (HD), 18 devamlı ayaktan periton diyalizi (DAPD) tadavisindeki, yaş ortalaması 46,4±14yıl ve diyaliz süresi 37,8±30 ay olan 35 hastada L-Carnitine (LC) tedavisinin eritrosit osmotik frajilite (EOF) üzerine etkileri incelendi. Yaş ortalaması 43,8±7 yıl olan 44 sağlıklı birey kontrol olarak alındı. Hastalara 4 ay 2g/gün, izleyen 12 ay 20-25 mg/kg/haftada 3 gün, toplam 16 ay LC tedavisi (HD'de diyaliz sonu İ.V.,DAPDde P.O.) uygulandı. Başlangıçta kontrolden düşük olan (P<0.000) hemoglobin (Hb), hematokrit (Hct), eritrosit (Er) değerlerinde tedavi ile 4 ve 16 ayda artma (P<0.0005,<0.005 ve <0.05) oldu. Tedavi kesildikten 4 ay sonra Hb yüksek kaldı (P<0.005). Yirmi hastada yüksek olan EOF(%0.53) 16ayda düştü (%0.42). LC kesildikten 4 ay sonra (%0.48) başlangıçdan düşük olan yükselme (P<0.005) gözlendi. Plazma serbest Carnitine, 16 ayda belirgin yükseldi (P<0.000). Bulgularımız, LC tedavisinin diyaliz hastalarındaki anemiyi düzeltmede EOF'ni azaltıcı etkisinin önemli rol aldığını göstermektedir.
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