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HEMODİYALİZ HASTALARINDA LOW-FLUX DİYALİZÖRÜN SERUM LEPTİN DÜZEYİNE ETKİSİ

EFFECT OF LOW-FLUX DIALYSER ON SERUM LEPTİN İN PATIENTS ON HEMODIALYSIS

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Abstract (2. Language): 
This study performed on 27 stable Hemodialysis (HD) patients with mean age 41,9 ± 75 years to investigate effect of the low-flux dialyser on serum leptin during HD. And 27 healthy subjects with mean age 42,7 11 years were included as a control. In both groups, fasting blood samples and in patient group at the end of 4 hours HD, fasting blood samples were drown-out to investigation biochemically. When compared to the controls, body mass index (BMI), haemoglobin (Hb), Hematocrit (Hct), in serum urea, creatinine, total protein, albumin (p<0.000), total cholesterol (p<0.001) were lower, C-peptide (p<0.000), insulin (p<0.001) were higher and basal mean leptin value was higher (11.5 16 ng/ml) but not significant then the control's (6.3 2 ng/ml) in HD group.Serum Leptin was significantly decreased (7.6 12 ng/ml) at the end of 4 hours HD (p<0.000). Controversialy to previous studies, we observed that low-flux dialyser decreased the serum leptin during HD session.
Abstract (Original Language): 
Hemodiyaliz (HD) tedavi seansında , Low-flux diyalizörün serum leptin düzeyine etkisini araştırmak için düzenli HD tedavisindeki yaş ort. 41.9±13 yıl olan 27 hasta çalışmaya alındı. Yaş ort. 42.7±11 yıl olan 27 sağlıklı birey kontrol olarak alındı. Her iki grubun sabah açlık ve hastalarda sıvı çekimi yapılmadan uygulanan HD tedavisinden 4 saat sonra açlık kan örnekleri alınarak incelendi ve vücut kitle indeksi (7Kİ) kg/m2 olarak hesaplandı. Hastalardaki VKİ, bazal hemoglobin (Hb),hematokrit (Hct), serum üre, kreatinin, total protein, albumin (p<0,000),total kolesterol (p<0,001) değerleri kontrol grubundan düşük, C-Peptit (p<0,000),insulin (p<0.001) ve serum leptin değeri (11,5±16 ve 6,3±2 ng/ml) anlamsız derecede yüksek bulundu. Bulgularımız, diyaliz sonundaki (Hb,Hct değerinde değişme olmadan) leptindeki belirgin düşmenin (7,6±12 p<0,000), low-flux diyalizörün leptine geçirgenliğini göstermektedir.
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REFERENCES

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