Buradasınız

Anasayfa » Content

HEMODİYALİZ HASTALARINDA LOW-FLUX DİYALİZÖRÜN SERUM LEPTİN DÜZEYİNE ETKİSİ

EFFECT OF LOW-FLUX DIALYSER ON SERUM LEPTİN İN PATIENTS ON HEMODIALYSIS

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 1999

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
This study performed on 27 stable Hemodialysis (HD) patients with mean age 41,9 ± 75 years to investigate effect of the low-flux dialyser on serum leptin during HD. And 27 healthy subjects with mean age 42,7 11 years were included as a control. In both groups, fasting blood samples and in patient group at the end of 4 hours HD, fasting blood samples were drown-out to investigation biochemically. When compared to the controls, body mass index (BMI), haemoglobin (Hb), Hematocrit (Hct), in serum urea, creatinine, total protein, albumin (p<0.000), total cholesterol (p<0.001) were lower, C-peptide (p<0.000), insulin (p<0.001) were higher and basal mean leptin value was higher (11.5 16 ng/ml) but not significant then the control's (6.3 2 ng/ml) in HD group.Serum Leptin was significantly decreased (7.6 12 ng/ml) at the end of 4 hours HD (p<0.000). Controversialy to previous studies, we observed that low-flux dialyser decreased the serum leptin during HD session.
Bookmark/Search this post with
Abstract (Original Language): 
Hemodiyaliz (HD) tedavi seansında , Low-flux diyalizörün serum leptin düzeyine etkisini araştırmak için düzenli HD tedavisindeki yaş ort. 41.9±13 yıl olan 27 hasta çalışmaya alındı. Yaş ort. 42.7±11 yıl olan 27 sağlıklı birey kontrol olarak alındı. Her iki grubun sabah açlık ve hastalarda sıvı çekimi yapılmadan uygulanan HD tedavisinden 4 saat sonra açlık kan örnekleri alınarak incelendi ve vücut kitle indeksi (7Kİ) kg/m2 olarak hesaplandı. Hastalardaki VKİ, bazal hemoglobin (Hb),hematokrit (Hct), serum üre, kreatinin, total protein, albumin (p<0,000),total kolesterol (p<0,001) değerleri kontrol grubundan düşük, C-Peptit (p<0,000),insulin (p<0.001) ve serum leptin değeri (11,5±16 ve 6,3±2 ng/ml) anlamsız derecede yüksek bulundu. Bulgularımız, diyaliz sonundaki (Hb,Hct değerinde değişme olmadan) leptindeki belirgin düşmenin (7,6±12 p<0,000), low-flux diyalizörün leptine geçirgenliğini göstermektedir.
FULL TEXT (PDF): 
PDF icon pdf_tndt_255.pdf
  • 3
124-127
  • Turkish

REFERENCES

References: 

1. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994; 372: 425¬432.
2. Bray GA, York DA. Clinical rewiev 90. Leptin and clinical medicine: a new piece in the puzzle of obesity.
J Clin Endocrinol Metab 1997; 82: 2771-2776.
3. Stenvinkel P, Heimbtlrger O, Lonnqvist F. Serum leptin concentrations correlate to plasma insulin concentrations independent of body fat content in chronic renal failure. Nephrol Dial Transplant 1997; 12:
1321-1325.
4. Young GA, Woodrow G, Kendall S, et al. Increased plasma leptin/fat ratio in patients with chronic renal failure: a cause of malnutrition? Nephrol Dial
Transplant 1997; 12: 2318-2323.
5. Nishizawa Y, Shoji T, Tanaka S, et al. Plasma leptin level and its relationship, with body composition in hemodialysis patients. Am J Kidney Dis 1998; 31: 655¬661.
6. Coyne DW, Dagogo-Jack S, Merabet E, Audrian J, Landt M. High-flux dialysis lowers plasma leptin concentration in chronic dialysis patients. Am J Kidney Dis 1998; 32: 1031-1035
7. Heimbürger O, Lonnqvist F, Danielsson A, Nordenstrom J, Stenvinkel P. Serum immunoreactive leptin concentration and its relation to the body fat content in chronic renal failure. J Am Soc Nephrol 1997; 8: 1423-1430
8. Merabet E, Dagogo-Jack S, Coyne DW, et al. Increased plasma leptin concentration in end-stage renal disease.
J Clin Endocrinol Metab 1997; 82: 847-850.
9. Stenvinkel P, Lonnqvist F, Schalling M. Molecular studies of leptin: implications for renal disease. Nephrol
Dial Transplant 1999; 14: 1103-1112.
10. Wiesholzer M, Harm F, Hauser AC, Pribasnig A, Balcke P. Inappropriately high plasma ieptin levels in obese haemodialysis patients can be reduced by high flux haemodialysis and haemodiafiltration. Clin Sci 1998;94:431-435.
11. Owen WF Jr, Lew NL, Lowrie EG, Lazarus JM. The urea reduction ratio and serum albumin concentrations as predictors of mortality in patients undergoing
hemodialysis. N Engl J Med 1993; 329: 1001-1006.
12. İkizler TA, Hakim RM. Nutrition in end-stage renal
disease. Kidney Int 1996; 50: 343-357.
13. Sharma K, Considine RV. The ob protein (leptin) and
kidney. Kidney Int 1998; 53: 1483-1487.
14. Sharma K, Considine RV, Michael B, et al. Plasma leptin is partly cleared by the kidney and is elevated in hemodialysis patients. Kidney Int 1997; 51: 1980-1985.
15.
Doğuka
n A, Utaş C. Kronik böbrek yetersizliği ve leptin. Türk Nefroloji Diyaliz ve Transplantasyon
Dergisi 1998;3:129-131.
16. Widjaja A, Stratton İM, Horn R, Holman RR, Turner R, Brabant G. UKPDS 20: plasma leptin, obesity, and plasma insulin in type 2 diabetic subjects. J Clin
Endocrinol Metab 1997; 82: 654-657.
17. Nordfors L, Lonnqvist F, Heimbürger O, Danielsson A, Schalling M, Stenvinkel P. Low leptin gene expression and hyperleptinemia in chronic renal failure. Kidney Int
1998; 1267-1275.
18. Nakazono H, Nagake Y, Ichikawa H, Makino H. Serum leptin concentrations in patients on hemodialysis.
Nephron 1998;80:35-40.
19. Nishikawa M,Takagi T,Yoshikawa N,et al. Measurement of serum leptin in patients with chronic renal failure on hemodialysis. Clin Nephrol 1999;51:296-303.

Thank you for copying data from http://www.arastirmax.com