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L-CARNÎTÎN TEDAVİSİNİN HEMODİYALİZ VE PERİTON DİYALİZİ HASTALARINDA ERİTROSİT YAŞAM SÜRESİNE ETKİSİ

THE EFFECT OF L-CARNITINE TREATMENT ON ERYTHROCYTE SURVIVAL IN HEMODIALYSIS AND PERITONEAL DIALYSIS PATIENTS

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Abstract (2. Language): 
Renal anemia improves after L-Carnitine (L-C) administration to patients on chronic dialysis due to causes that remain unclear. Our study was designed on dialysis patients to investigate effects of L-C on anemia and on erythrocyte survival (ES) which is important in anemia. This study consisted 15Hemodialysis (HD), 16 Continuous Ambulatory Peritoneal Dialysis (DAPD) patients and 44 healthy subjects. Patients received L-C 2 g /day for 4 months then 20-25 mg/kg 3 days a week, for following 12 months. At initial, after 4 and 16 months biochemically, and initial, after 6, 12 months ES were investigated. Initial free carnitine (FC) level in patients (was lower than that of controls and increased during 16 months. An increase in Haemoglobin -Hb, Hematocrit-Htc, Erythrocytes —Er was occurred 4 months after, and continued in following 12 months. ES was prolonged from 16±6 days to 22.6±10days in 6th and to 24.2±6 days in 12th months. In serum, Albumin (Alb) increased, creatinin decreased in 16th month in DAPD group. Alb increased , urea decreased n HD group. Our findings suggest that the improvement in anemia was mainly due to prolonged ES with L-C treatment. We also thought that L-C might has an effect on Hb sentesis.
Abstract (Original Language): 
L-C'amitine'in diyaliz hastalarındaki anemiyi düzeltici mekanizması tam açıklanamamıştır. Bu nedenle çalışmamızda, diyaliz hastalarında L-Carnitine tedavisinin anemi ve eritrosit yaşam süresi (EYS) üzerine etkilerini araştırdık. 15i Hemodiyaliz (HD), 16'sı Devamlı Ayaktan Periton Diyaliz (DAPD) tedavisi gören 31 hasta ve 44 sağlıklı birey çalışmaya alındı. Hasta gruplarına 4 ay 2gr/gün, izleyen 12 ay 20-25 mg/kg/haftada 3gün L-C (HD'de İ.V..DAPD de P.O.) uygulandı. Başlangıç, 4 , 16 ay sonra biyokimyasal ve başlangıç, 6, 12 ay sonra Cr-51 ile EYS incelemeler yapıldı. Başlangıçta kontrolden düşük olan Hemoglobin-Hb, Hematokrit -Htc, eritrosit -Er değerleri tedaviden 4 ve 16 ay sonra yükseldi. Kontrol grubundan (29.4±7 gün) düşük olan hasta EYS, 16±6 günden 6 ayda 22.6±10 ve 12 ayda %51 yükselişle 24.2±6 güne çıktı. DAPD'de kreatinin (sKr), HD grubunda üre düştü.Her ikigrubda serum albumin (Alb) ve total protein (t.prot) arttı. Kontrol grubundan düşük olan hasta gruplarının plazma free camilin (FC) değerleri belirgin derecede yükseldi Bulgularımız, L-C nin anemiyi düzeltici etkisinin öncelikle EYS'nin uzamasından kaynaklandığını göstermekte ve Hb sentezine etkisini düşündürmektedir.
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