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NORMAL EJEKSÎYO N FRAKSİYONU OLAN HEMODÎALÎZ HASTALARINDA SOL VE SAĞ VENTRİKÜL PERFORMANSININ SÎSTOLÎK ZAMAN ARALIKLARI İLE DEĞERLENDİRİLMESİ

THE ASSESSMENT OF LEFT AND RIGHT VENTRICULAR PERFORMANCE WITH SYSTOLIC TIME INTERVALS IN HEMODIALYSIS PATIENTS WITH NORMAL EJECTION FRACTION

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 1999

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
In this controlled study, left (LV) and right (RV) ventricular systolic time intervals (STI) were investigated in hemodialysis patients (HDp) with normal myocardial systolic function as assessed by ec'ocardiographic indicators like ejection fraction (EF). Echocardiographic findings in 88 HDp (M:F 47:41, mean age 35±11 years) and 73 healthy controls (M:F 31:42, mean age 36^10 years) were compared for STI parameters (prejection period (PEP), ejection time (ET) and STI index (PEP/ET)). Left ventricular PEP (114±21 ms vs. 95.4±3.6 ms, p<0.001) and STI index (0.41±0.11 vs 0.34±0.02, p<0.001) were higher in the HDp as compared to controls. There were no difference in RV STI parameters between two groups. The deteriorations of STI parameters in HDp were independent ofL V hypertrophy and hypertension. It was concluded that while RV performance seems not to be influenced by uremia, LV STI indexes deteriorate before an overt systolic dysfunction (normal EF), and impairment of STI indexes appear to be markers ofuremic cardiomyopathy, independent ofLV mass or hypertension.
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Abstract (Original Language): 
Bu kontrollü çalışmada, global ejeksiyon fraksiyonu (EF) normal bulunan hemodializ hastalarında (HDp), sol (LV)ve sağ (RV) ventrikül sistolik zaman aralıkları (STİ) araştırıldı. Dialize giren 88 hasta (E:K 47:41, ortyaş 35±11 yıl) ile 73 sağlıklı birey (E:K 32:41, ort yaş 36± 10 yıl) ekokardiyografik olarak STI parametreleri (Preejeksiyon periyod (PEP), ejeksiyon zamanı (ET) ve STI indeks (PEP/ET)) bakımından karşılaştırıldı. Hemodializ hastalarında LV için PEP (114±21 ms e karşı 95.4±3.6ms, p<0.001) ve STIindeks (0.41±0.11 e karşı 0.34±0.02, p<0.001) kontrol grubuna göre anlamlı olarak daha yüksek bulunurken, RV sistolik zaman aralıkları normalden farklı bulunmadı. Hemodializ hastalarında artmış sol ventrikül STI indeksi ve PEP, LV hipertrofisi ve hipertansiyondan bağımsız idi. Sonuç olarak, üremik hastalarda RVperformansı üremiden etkilenmez görünürken, sol ventrikül STI parametreleri aşikar sistolik disfonksiyondan önce (normal EF ve FS), LV kitlesinden ve hipertansiyondan bağımsız olarak bozulmakta ve bu bulgu üremik kardiyomyopatinin göstergesi olarak gözükmektedir.
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  • 3
133-137
  • Turkish

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