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ESANSÎYEL HİPERTANSİYONDA İNSÜLİN, LEPTİN, C-PEPTİD ve LİPOPROTEİNLER

INSULIN, LEPTİN, C-PEPTIDE AND LIPOPROTEINS EN ESSENTIAL HYPERTENSION

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Abstract (2. Language): 
Glucose intolerance, hyperinsulinemia, hyperlipidemia accompanied with essantial hypertension (HT) increase atherosclerosis. In order to evaluate metabolic status, in 209 non-complicated HT patients, with mean blood pressure (BP) 160/100 mmHg and 114 healty subjects, with mean BP 119/78 mmHg in Thrace region were covered. Fasting serum insulin, C-peptide, leptin, uric acid (UA), serum creatinine (Cr), fasting blood sugar (FBS), total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL) were measured. Body mass index (BMI-kg/m ) was calculated. There were no differences observed between two groups in age and sex. In HT group, BMI, FBS, insulin, C-peptide, leptin, UA, TG were found to be high. BP and BMI were found to be pozitive correlated with insulin, C-peptide, leptin, TG also BP with UA and BMI with FBS. Significant metabolic disturbance were observed in HTfemales than those controls. Decreasing in serum Na+ with dietary salt restriction, elevation Hb, UA in smokers were observed. We thought that metabolic disturbances in our patients, might be decreased by life style changes.
Abstract (Original Language): 
Esansiyel Hipertansiyondaki (HT) glukoz intoleransı, hiperinsulinemi ve lipid bozukluğu aterosklerozu artırmaktadır. Trakya Bölgesindeki HTlularda metabolik yapıyı araştırmak için organ komplikasyonu oluşmamış, ort. Kan Basıncı (KB) 160/100 mmHg olan 209 HT'lu ve ort. KB 119/78 mmtig olan 114 sağlıklı birey çalışmaya alındı. Açlık serumunda insulin, C-peptit, leptin, ürik asit (UA), kreatinin (SKr), açlık kan şekeri (AKŞ), total kolesterol (TK), trigliserit (TG), yüksek dansiteli lipoprotein (HDL), vücut kitle indeksi (VKİ) ölçüldü. Kontrol grupla yaş, cins farkı olmayan HT grubunda VKİ, AKŞ, insülin, C-peptit, leptin, UA, TG yüksek ve İnsülin, C-peptit, leptin, TG ile KB, VKİ arasında, UA ile KB, AKŞ ile C-peptit ve VKİ arasında doğrusal pozitif ilişki bulundu. HT grubundaki erkeklerde, hemoglobin (Hb), SKr, UA, TG yüksek, HDL düşük bulunurken kontrol gruba göre hipertansif kadınlarda metabolik bozukluk belirgindi. Sigara içenlerde Hb, UA 'de yükseklik, diyetle tuz azaltılmasında serum Na+ 'unda düşme gözlendi. Bulgularımız, hastalarımızdaki metabolik bozukluğun yaşam biçimi düzenlenmesi ile azaltılabileceğini düşündürmektedir.
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REFERENCES

References: 

1. Reaven GM. Role of insulin resistance in human disease. Diabetes 1998; 37: 1595-1607
2. Kaplan NM. The deodly quartet: Upper-body obesity, glucose intolerance, hypertriglyceridemia and
hypertension. Arch Intern Med 1989; 149: 1514-1520
3. Sechi LA, Catena C, Zingaro L, De Carli S, Bartoli E. Hypertension and abnormalities of carbonhydrate metabolism possible role of the sympathetic nervous
systeem. Am J Hypertens 1997; 19: 678-682
4. Ferrannini E, Buzzigoli G, Bonodonna R et al. Insulin resistance in essential hypertension. N Eng J Med 1987; 317:350-357
5. Grandi AM, Gaudio G, Fachinetti A et al. Hyperinsulinemia, family history of hypertension, and essential hypertension. Am J Hypertens 1996; 9: 732¬738
6. Mantzoros CS, Flier JS. Insulin resistance: The clinical
spectrum. Adv Endocrnol Metab 1995;6:193-232
7. Considine RV, Sinha MK, Heiman ML et al. Serum
immoreactive-Leptin concentrations in normal-weight
and obese humans. N Eng J Med 1996; 334: 292-295
8. Agata J, Masuda A, Takada M, et al. High plasma immunoreactive leptin level in essential hypertension.
AmJHypertens 1997; 10: 1171-1174
9. Hirose H, Sito I, Tsujioka M, Mori M, Kowabe H, Saruta T. The obese gene product, leptin; possible role in obesity related hypertension in addolescents. J
Hypertens 1998; 16: 2007-2012
10. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homoloque. Nature 1994; 372: 425¬432
11. Considine RV, Considine EL, Williams CJ, Hyde TM,
Caro JF. The hypothalamic leptin receptor in humans: Identification of incidental sequence polymorphisms and absence of the db/db mouse and fa/sa rat mutations.
Diabetes 1996; 19:992-994
12. Segal KR, Landt M, Klein S. Relationship between insulin sensitivity and plasma leptin concentration in
lean and obese men. Diabetes 1996; 45: 988-991
13. Ceddia RB, William Jr WN, Lima FB, Carpinelli AR,
Curi R. Pivotal role of leptin in insulin effects. Braz J Med Res 1998; 31: 715-722
14. Shek EW, Brands MW, Hall JE. Chronic leptin infusion increases arteriel pressure. Hypertension 1998; 31(ipt 2): 409-414
15. Reisin E, Messerli FH. Obesity-related hypertension: mechanisms, cardiovascular risks, and heredity. Curr
Opin Nephrol Hypertens 1995; 4: 67-71
16. van Lenthe FJ, van Mechelen W, Kemper HCG, Twisk JWR. Association of a central pattern of body fat with blood pressure and lipoproteins from adoloscence into adulthood.
Am J Epidemiol 1998;147:686-693
17. Endre T, Mattiasson I, Berglund G, Hulthen UL. Insulin and renal sodium retantion in hypertension-prone men.
Hypertension 1994; 23: 313-319
18. Sharma K, Considine RV. The ob protein (leptin) and
the kidney. Kidney Int 1998; 53: 1483-7
19. Abrams JJ, Ginsberg H, Grundy SM. Metabolism of cholesterol and plasma triglycerides in nonkinetic
diabetes mellitus. Diabetes 1982; 31: 903-910
20. Trevor OJ, Dorothy BJ, Margaret B et al. Plasma insulin and lipoprotein concentrations: An atherogenic associations? Am J Epidemiol 1983; 118:326-337
21. Chen CH, Tsai ST, Cluang JH et al. Population-based study of insulin, C-peptide, and blood pressure in Chinese with normal glucose tolerance. Am J Cardiol 1995;76:585-588
22. Weigle DS, Hutson AM, Kramer JM et al. Leptin does not fully account for the satiety activity of adiposa tissue-conditioned medium. Am J Physiol 1998; 275: R976-R985
204
23. Lemne C, Hamsten A, Karpe F, Nilsson-Ehle P, de Faire U. Dyslipoproteinemic changes in borderline hypertension. Hypertension 1994; 24: 605-610
24. Islam AHMV, Yamashita S, Katoni K et at. Fasting plasma insulin levels is an importanat risk factor for the development of complications in Japanese obese children-results from a cross-sectional and longitudional study. Metabolism 1995; 44: 478-485
25. Lithell H. Hypertension and hyperlipidemia. Am J
Hypertens 1993; 6: 303S-308S
26. Messerli FH, Frohlich ED, Dreslinski GR, Suare DH,
Arstimino GG. Serum uric acid in essential hypertension: An Indicator of renal vascular
involvement. Ann Intern Med 1980; 93: 817-821
27. Mohles RW, Palaoğlu KE, Atak Z et al. Turkish heart
study: Lipids, lipoproteins and apolipoproteins. J Lipid
Res 1995; 36: 839-861
28. Julius S, Jamerson K, Mejia A, Krause L, Schork N, Jones K. The association of borderline hypertension with target organ changes and higher coronary risk: Tecumseh Blood Pressure study. JAMA 1990; 264: 354-358
29.
Şe
n S, Çeçen Ş, Sevinir Ş, Çiftçi Ş, Çiftçi Ş. Esansiyel
Hipertansiyonda erken evre renal etkilenme göstergeleri. Türk Nefroloji Diyaliz Transplant 1999; 8: 147-151
30. Mantzoros CS. The role of leptin in human obesity and disease. A review of current human obesity and disease of current evidence. Ann Intern Med 1999; 130: 671¬680
205

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