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ESANSÎYEL HİPERTANSİYONDA İNSÜLİN, LEPTİN, C-PEPTİD ve LİPOPROTEİNLER

INSULIN, LEPTİN, C-PEPTIDE AND LIPOPROTEINS EN ESSENTIAL HYPERTENSION

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 1999

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Glucose intolerance, hyperinsulinemia, hyperlipidemia accompanied with essantial hypertension (HT) increase atherosclerosis. In order to evaluate metabolic status, in 209 non-complicated HT patients, with mean blood pressure (BP) 160/100 mmHg and 114 healty subjects, with mean BP 119/78 mmHg in Thrace region were covered. Fasting serum insulin, C-peptide, leptin, uric acid (UA), serum creatinine (Cr), fasting blood sugar (FBS), total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL) were measured. Body mass index (BMI-kg/m ) was calculated. There were no differences observed between two groups in age and sex. In HT group, BMI, FBS, insulin, C-peptide, leptin, UA, TG were found to be high. BP and BMI were found to be pozitive correlated with insulin, C-peptide, leptin, TG also BP with UA and BMI with FBS. Significant metabolic disturbance were observed in HTfemales than those controls. Decreasing in serum Na+ with dietary salt restriction, elevation Hb, UA in smokers were observed. We thought that metabolic disturbances in our patients, might be decreased by life style changes.
Abstract (Original Language): 
Esansiyel Hipertansiyondaki (HT) glukoz intoleransı, hiperinsulinemi ve lipid bozukluğu aterosklerozu artırmaktadır. Trakya Bölgesindeki HTlularda metabolik yapıyı araştırmak için organ komplikasyonu oluşmamış, ort. Kan Basıncı (KB) 160/100 mmHg olan 209 HT'lu ve ort. KB 119/78 mmtig olan 114 sağlıklı birey çalışmaya alındı. Açlık serumunda insulin, C-peptit, leptin, ürik asit (UA), kreatinin (SKr), açlık kan şekeri (AKŞ), total kolesterol (TK), trigliserit (TG), yüksek dansiteli lipoprotein (HDL), vücut kitle indeksi (VKİ) ölçüldü. Kontrol grupla yaş, cins farkı olmayan HT grubunda VKİ, AKŞ, insülin, C-peptit, leptin, UA, TG yüksek ve İnsülin, C-peptit, leptin, TG ile KB, VKİ arasında, UA ile KB, AKŞ ile C-peptit ve VKİ arasında doğrusal pozitif ilişki bulundu. HT grubundaki erkeklerde, hemoglobin (Hb), SKr, UA, TG yüksek, HDL düşük bulunurken kontrol gruba göre hipertansif kadınlarda metabolik bozukluk belirgindi. Sigara içenlerde Hb, UA 'de yükseklik, diyetle tuz azaltılmasında serum Na+ 'unda düşme gözlendi. Bulgularımız, hastalarımızdaki metabolik bozukluğun yaşam biçimi düzenlenmesi ile azaltılabileceğini düşündürmektedir.
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