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PROTEİNÜRİK HASTALARDA OKSIDATIF "STRESS" VE ESER ELEMENT SEVİYELERİ

OXIDATIVE STRESS AND TRACE ELEMENTS IN PROTEINURIC PATIENTS

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 1999

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
After having shown decreased red cell deformability in proteinuric patients we planned this experimental study, in order to investigate a possible role of free oxygen radicals and the antioxidant system. Twelve proteinuric patients were compared with 20 age and sex-matched healty controls. Erythrocyte and plasma malonyldialdehyde, erythrocyte glutathione, erythrocyte glutathione reductase, erythrocyte sodium-dismutase and erythrocyte peroxidase activities were measured. Because of a possible effect of trace elements on the metalloenzyme activities zinc, copper and iron levels in blood and urine were determined. It is suggested that the red cell deformability was decreased because of increased malonyldialdehyde levels and decreased activity of the antioxidant system, may be due to high loss of urinary trace elements.
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Abstract (Original Language): 
Proteinürik hastalarda eritrosit deformabilitesinin azaldığını gösterdikten sonra, buna sebep olabilecek etkenlerden biri serbest oksijen radikallerinin ve/veya antioksidan sistemin değişimleri olabileceğini düşünerek, eldeki çalışma planlandı. Onikiproteinürik hasta yaş ve cins olarak uygun, yirmi sağlıklı kişi ile karşılaştırıldı. Eritrosit ve plazma malonildialdehid, eritrosit glutathione, eritrosit glutathion-redüktaz aktivitesi, eritrosit glutathione peroksidaz ve eritrosit sodyum dismutaz aktiviteleri, oksidatif ve antioksidan sistemin enzimleri olarak belirlendi. Antioksidanlar eser elementlere bağlı metalloenzimler olduklarından ötürü, onların değişimini etkileyebilecek plazma ve idrar çinko, bakır ve demir seviyeleri ölçüldü. Eritrosit deformabilitesi intraselüler oksidasyon stresine ve azalmış antioksidan sisteme bağlı olarak bozulmuş olduğu kabul edildi. İdrarda aşırı eser element kaybı ise azalmış savunma mekanizmasının temelinde yattığı düşünüldü.
FULL TEXT (PDF): 
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  • 4
213-218
  • Turkish

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