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SIFIR SAAT BÎOPSÎLERDE SAPTANAN MORFOLOJİK BULGULAR VE ERKEN DÖNEMDE GREFT FONKSİYONUNA ETKÎSÎ

MORPHOLOGICAL FINDINGS OF ZERO HOUR NEEDLE BIOPSIES AND THEIR INFLUENCE ON EARLY GRAFT FUNCTION

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 2000

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
In our country, kidney donors are usually elder relatives of patients. It's possible that these kidneys may have histopathological findings related to aging and causes the complexicity at kidney functions after transplantation and also morphological findings of newly obtained transplant kidney biopsies. In this study, we investigated the incidence and intensity of findings in zero hour needle biopsies (ZHNB) and their correlation with early creatinine values. In 84% of ZHNB histopathological findings have been determined. Most frequent findings were intimal fibrosis and intimal hyaline deposits. The findings were significant in 27% of ZHNB. Kidneys are harvested from elder donors and having significant histopathological changes have high creatinine values. The sum of histopathological scores and older age are correlated with higher levels of creatinine values. Our findings show that in ZHNB histopathological changes related to donors are present. These findings are valuable to predict the graft function and to obtain knowledge for other transplant biopsies.
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Abstract (Original Language): 
Ülkemizde böbrek transplantasyonları genelde canlı, yaşlı, akraba vericilerden sağlanan böbreklerle yapılmaktadır. Bu böbreklerin yaşla ilişkili birtakım histopatolojik bulgular taşıması ve bu bulguların transplant sonrası böbrek fonksiyonlarını ve alınan yeni biopsilerdeki morfolojik bulguları kompleks hale getirmesi olasıdır. Bu çalışmada nakil sırasında alınan sıfır saat biopsilerde (SSB) saptanan bulguların insidansı, yoğunluğu ve erken dönem kreatinin değerleri ile korelasyonu araştırılmıştır. SSBlerin %84'ünde histopatolojik bulgu saptanmıştır. En sık saptanan değişiklikler intimal fibrozis ve intimal hyalinizasyondur. SSB'lerin %2Tsinde bulgular belirgindir. Belirgin bulgulu olgularda ve yaşlı vericilerde kreatinin değerleri daha yüksektir. Histopatolojik skor toplamları ve yaş, kreatinin değer yüksekliği ile de kor eledir. Bulgularımız diğer çalışmalar gibi sıfır saat biopsilerde verici değişikliklerinin olduğunu göstermektedir. Bu bulgular diğer biopsiler için önemli bilgiler taşıdıkları gibi greft fonksiyonunu tahmin etmede de değerlidirler.
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  • 1
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  • Turkish

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