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STANDART TEDAVİLERE DÎRENÇLÎ MEMBRANOPROLÎFERATÎF GLOMERULONEFRÎTTE MYCOPHENOLATE MOFETIL TEDAVİSİ

MYCOPHENOLATE MOFETIL THERAPY FOR MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS REFRACTORY TO STANDARD TREATMENTS

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 2000

Key Words:

Keywords (Original Language):

Author NameUniversity of Author
Abstract (2. Language): 
Mycophenolate mofetil, a non-competitive inhibitor of inosine monophosphate dehydrogenase, is a new treatment agent for glomerular diseases. A 22-year-old male patient with resistant membranoproliferative glomerulonephritis was treated with mycophenolate mofetil in combination with low-dose corticosteroid and cyclosporine-A treatment. The treatment resulted in significant reduction in proteinuria and increase in creatinine clearence in 4th month of the' therapy. Although clinical experience in non-transplant uses of mycophenolate mofetil remains anectodal, the drug may be a useful primary or adjunctive therapy in glomerulonephritides.
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Abstract (Original Language): 
Inozin monofosfat dehidrogenazın yarışmasız inhibitörü olan mycophenolate mofetil glomeruler hastalıklar için yeni bir tedavi ajanıdır. Dirençli membranoproliferatif glomerulonefriti olan 22 yaşındaki bir erkek hastaya düşük doz, oral kortikosteroid ve siklosporin-A tedavisine ek olarak mycophenolate mofetil verilmiştir. Tedavinin dördüncü ayında proteinürinin düzeyinde anlamlı azalma ve kreatinin klirensinde anlamlı artış olduğu görülmüştür. Mycophenolate mofetil'in transplantasyon dışı kullanımıyla ilgili klinik deneyimler anektodal olmakla birlikte,glomerulonefritlerin tedavisinde birincil ya da adjuvan ilaç olarak kullanılabilir.
FULL TEXT (PDF): 
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  • 2
115-117
  • Turkish

REFERENCES

References: 

1. Jayne D : Non-transplant uses of mycophenolate mofetil . Curr Opin Nephrol Hypertens 1999 ; 8: 563¬567.
2. Ishikawa H : Mizoribine and mycophenolate mofetil . Curr Med Chem 1999; 6: 575-597.
3. Hauser IA, Renders L, Radeke HH, Sterzel RB, Goppelt-Struebe M: Mycophenolate mofetil inhibits rat and human mesangial cell proliferation by guanosine depletion. Nephrol Dial Transplant 1999; 14: 58-63.
4. Ziswiler R, Steinmann-Niggli K, Kappeler A, Daniel C, Marti HP: Mycophenolic acid : a new approach to the therapy of experimental mesengial proliferative glomerulonephritis. J Am Soc Nephrol 1999; 9:2055¬2066.
5. Jonsson CA, Svensson L, Carlsten H: Beneficial effect of the inosine monophosphate dehydrogenase inhibitor mycophenolate mofetil on survival and severity of glomerulonephritis in systemic lupus erythematosus (SLE)-prone MRLlpr/lpr mice. Clin Exp Immunol
1999; 116:534-541.
6. McMurray RW, Elbourne KB, Lagoo A, Lai S:
Mycophenolate mofetil suppresses autoimmunity and mortality in the female NZBxNZW Fl mouse model of systemic lupus erythematosus. J Rheumatol 1998;
25:2364-2370.
7. Van Bruggen MC, Walgreen B, Rijke TP, Berden JH:
Attenuation of murine lupus nephritis by mycophenolate mofetil. J Am Soc Nephrol 1998;
9:1407-1415.
8. Corna D, Morigi M, Facchinetti D, Bertani T, Zoja C, Remuzzi G : Mycophenolate mofetil limits renal damage and prolongs life in murine lupus autoimmune disease. Kidney Int 1997;51:1583-1589.
9. Dooley MA, Cosio FG, Nachman PH, Falkenhain ME,
Hogan SL, Falk RJ, Hebert LA: Mycophenolate mofetil therapy in lupus nephritis : clinical observations. J Am
Soc Nephrol 1999; 10:833-839.
10. Glicklich D, Acharya A : Mycophenolate mofetil therapy for lupus nephritis refractory to intravenous cyclophosphamide. Am J Kidney Dis 1998; 32:318¬322.
11. Penny MJ, Boyd RA, Hall BM: Mycophenolate mofetil
prevents the induction of active Heymann nephritis: association with Th2 cytokine inhibition. J Am Soc
Nephrol 1998; 9:2272-2282.
L2. Schiele J, Nowack R, Julian BA, van der Woude FJ: Treatment of immunoglobulin A nephropathy. Ann
Med Intern 1999; 150: 127-136.
13. Briggs WA, Choi MJ, Scheel PJ Jr : Successful
mycophenolate mofetil treatment of glomerular disease.
Am J Kidney Dis 1998; 31:213-217.
14. Nowack R, Gobel U, Klooker P, Hergesell O, Andrassy K, van der Woude FJ: Mycophenolate mofetil for maintenance therapy of Wegener's granulomatosis and microscopic polyangiitis: a pilot study in 11 patients with renal involvement. J Am Soc Nephrol 1999, 10: 1965-1971.

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