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DÎYALÎZ HASTALARINDA ERITROPOIETÎNÎN ERİTROSİT YAŞAM SÜRESİ, LÎPÎD PEROKSÎDASYONU VE ERİTROSİT ANTÎOKSÎDAN SİSTEME ETKÎSÎ

THE EFFECTS OF ERYTHROPOIETIN ON RED BLOOD CELL SURVIVAL, LIPID PEROXIDATION AND ERYTHROCYTE ANTIOXIDANTS IN DIALYSIS PATIENTS

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 2000

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Renal anemia improves after treatment of erythropoietin (EPO) but its mechanism is not clear. To evaluate the effect of erythropoietin on red blood cell survival (RBCS) and oxidant system which is important in renal anemia, 22 dialysis patients (17 hemodialysis, 5 continue ambulatory peritoneal dialysis) with mean age 41.7±14 yrs. and 44 healthy subjects with mean age 44.8±9yrs. were studied. 50Ib/kg EPO wasgiven-two day/weekly S.C. to patients and continued with 61 ±21 IU/kg for 16 months. In patients group, decreased hemoglobin, heamatocrite and erythrocytes values at initial were significantly increased at the end of four months than continued the elevation by 16 months. Serum albumin and transferrin values that lower at initial, increased after four months than continued further 12 months. Vitamin E, intraerythrocytes superoxide dismutase, plasma free carnitine increased and malonyldealdehyd decreased at the end of 16 months. Initial red blood cell survival (using Cr-51), was significantly lower than controls (18.4±6.7 vs. 29.4+7.2 d). It prolonged significantly after in both 6 (25.5±7.3 d) and 12 months (29.4±6.7 d). We observed that EPO treatment prolongs RBCS by decreasing lipid peroxidation and increasing antioxidants in dialysis patients.
Abstract (Original Language): 
Renal parankim kaybıyla azalan eritropoietin (EPO) tedavisi ile diyaliz hastalar ındaki anemi düzelmekte, ancak mekanizması tam bilinmemektedir. 17 'si hemodiyaliz (HD), 5 'i devamlı ayaktan periton diyaliz (DAPD) tedavisi gören yaş ortalaması 41.7±14 olan 22 diyaliz hastası ve yaş ortalaması 44.8±9yıl olan 44 sağlıklı birey çalışmaya alındı. Hastalara haftada 2 kez 50 U/kg S.C. EPO başlandı, hedeflenen %30 hematokrit (Htc) değeri için 61±21 U/kgla devam edildi. Hasta grubundaki; düşük olan hemoglobin (Hb), Htc ve eritrosit (Er) değerleri 4 aylık EPO tedavisi ile belirgin yükselmeyi 16 ayda korudu. Düşük olan serum albümin ve transferrin değerlerinin 4 aydaki yükselişi 16 ayda arttı. Kontrol grubundan düşük olan anti-oksidanlardan plazma E vitamini ve Er içi süperoksit dismutaz ve plazma serbest karnitini 16 ayda artarken, lipid peroksidasyon ürünü malonildialdehid düştü. Cr-51 ile ölçülen 'A eritrosit yaşam süresi (EYS) 10 sağlıklıda 29.4±7.2 ve 16 hastada 18.4±6.7 gün bulundu. Altı ve 12 aylık EPO tedavisi ile 25.5±7.3 ve 29.4±6.7 güne uzadı. Bulgularımız, EPO'in kemik iliğinde Er yapımı artırmasına ek olarak, oksidasyonu düzeltici etkiyle EYS'ni uzatarak anemiyi iyileştirdiğini göstermektedir.
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