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Mesane Kanserlerinde Tümör İle İlişkili Doku Eozinofilisinin Önemi Nedir?

What is the Importance of Tissue Eosinophilia Associated With Tumor in Bladder Carcinomas?

Journal Name:

  • Uludağ Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 2010

Key Words:

Keywords (Original Language):

Author Name
Abstract (2. Language): 
Should the presence of tissue eosinophilia be studied in tumors? Should the amount of tissue eosinophilia associated with tumor be specified in the pathology reports, or is dealing with this is just a waste of time and effort? When we check the literature, in many tumor types, tissue eosinophilia has a positive effect on the survival; however different tumor types deny this fact and show that eosinophils stimulate tumor growth via some mediators. In some tumors, its relationship with survival could not be demonstrated. A few studies, showing the effect of eosinophils on tumor in bladder carcinomas are present. The purpose of our study is to investigate the relationship of tissue eosinophilia with prognostic factors and survival in cases diagnosed with urothelial carcinoma, and eventually to contribute to the literature. Our retrospective study consisted of 90 urothelial carcinoma cases, diagnosed between 1996 and 2002. Clinical information related to the patients was collected and pathological cross-sections were re-examined. Cross-sections belonging to each patient were assessed in respect to histological grade, vascular or perineural invasion, lymph node metastasis and the number of eosinophils in the biggest area of magnification. The numbers of eosinophils were grouped as low, medium and high. As a result of he conducted statistical studies, a relationship between the number of tissue eosinophils and size of the tumor, histological grade, lymphovascular invasion, perineural invasion, lymph node metastasis and survival could not be found. More studies are necessary to prove the relationship of tissue eosinophilia in with survival in bladder carcinomas. Investigation of tissue eosinophilia in studies having more number of cases may be important in regard to tumor treatment, stimulation or suppression of eosinophilia with various agents and the inclusion of additional treatment options.
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Abstract (Original Language): 
Doku eozinofil varlığı tümörlerde araştırılmalı mıdır? Tümör ile ilişkili doku eozinofil miktarı patoloji raporlarında belirtilmeli midir, yoksa bununla uğraşmak sadece zaman ve emek kaybı mıdır? Literatüre bakıldığında birçok tümör tipinde doku eozinofilisinin sağ kalıma iyi etkisi mevcuttur, ancak farklı tümör tipleri bunu inkar etmekte, eozinofillerin bir takım mediatörler yardımıyla tümör büyümesini uyardığını göstermektedir. Bazı tümörlerde ise sağ kalım ile ilişkisi gösterilememiştir. Mesane tümörlerinde doku eozinofilisinin tümöre etkisini gösteren çok az sayıda araştırma mevcuttur. Çalışmamızdaki amaç ürotelyal karsinoma tanısı almış vakalarda, doku eozinofilisinin prognostik faktörler ve sağ kalım ile ilişkisini incelemek, bunun sonucunda literature katkıda bulunmaktır. Retrospektif çalışmamız 1996–2002 yılları arasında tanı almış 90 ürotelyal karsinoma olgusunu kapsamaktadır. Hastalara ait klinik bilgiler toplanıp, patoloji kesitlere tekrar bakıldı. Her hastaya ait kesitler histolojik grade, vasküler veya perinöral invazyon, lenf nodu metastazı ve en büyük büyütme alanındaki (HPFx400) eozinofil sayısına göre değerlendirildi. Eozinofil sayısı düşük, orta ve yüksek olarak gruplandırıldı. Yapılan istatistiki çalışmalar sonucunda doku eozinofil sayısının, tümör boyutu, histolojik grade, lenfovasküler invazyon, perinöral invazyon, lenf nodu metastazı ve sağ kalım ile ilişkisi bulunamamıştır. Mesane tümörlerinde doku eozinofilisinin sağ kalım ile ilişkisini kanıtlamak için daha fazla sayıda yayına ihtiyaç vardır. Daha büyük serili çalışmalarda doku eozinofilisinin araştırılması tümör tedavisine, eozinofilinin çeşitli ajanlarla stimülasyonu veya baskı- lanması gibi ek tedavi seçeneklerinin eklenmesi açısından yararlı olabilir.
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  • 3
85-88
  • Turkish

REFERENCES

References: 

1. Alkhabuli JO, High AS. Significance of eosinophil counting in
tumor associated tissue eosinophilia (TATE). Oral Oncol 2006;
42:849-50.
2. Samoszuk M. Eosinophils and human cancer. Histol
Histopathol 1997; 12:807-12.
3. Fernández-Aceñero MJ, Galindo-Gallego M, Sanz J, et al.
Prognostic influence of tumor-associated eosinophilic infiltrate
in colorectal carcinoma. Cancer 2000; 88:1544-8.
4. Alrawi SJ, Tan D, Stoler DL, et al.Tissue eosinophilic
infiltration: a useful marker for assessing stromal invasion,
survival and locoregional recurrence in head and neck
squamous neoplasia. Cancer J 2005; 11:217-25.
5. Ono Y, Ozawa M, Tamura Y, et al. Tumor-associated tissue
eosinophilia of penile cancer. Int J Urol 2002; 9: 82-7.
6. Wong DT, Bowen SM, Elovic A, et al. Eosinophil ablation and
tumor development. Oral Oncol 1999; 35: 496- 501.
7. Teoh SC, Siow WY, Tan HT. Severe eosinophilia in
disseminated gastric carcinoma. Singapore Med J 2000; 41: 232.
8. Busch C, Algaba F. The WHO/ISUP 1998 and WHO 1999
systems for malignancy grading of bladder cancer. Scientific
foundation and translation to one another and previous systems.
Virchows Arch 2002; 441: 105- 8.
9. Lowe D, Jorizzo J, Hutt MSR. Tumor associated eosinophilia:
A review. J Clin Pathol 1981; 34: 1343- 8.
10. Porta C, Moroni M, de Amici M. Eosinophils and serum
eosinophilic cationic proteins in interleukin- 2 based
immunotherapy for cancer. Br J Hematol 1998; 100: 607–9. B. Aytaç, ark.
88
11. Tajima K, Yamakawa M, Inaba Y, et al. Cellular location of
interleukin-5 expression in rectal carcinoma with eosinophilia.
Hum Pathol 1998; 29: 1024–7.
12. Lowe D, Fletcher CDM. Eosinophilia in squamous cell
carcinoma of the oral cavity, external genitalia and anusclinical correlations. Histopathology 1984; 8: 627–32
13. Ayhan A, Altintas A, Tuncer ZS, et al. Prognostic value of
mitotic activity, eosinophilic and inflammatory reaction in stage
I cancer of the uterine cervix. Eur J Surg Oncol 1992; 18: 264–
6.
14. Leighton SE, Teo JG, Leung SF, et al. Prevalence and
prognostic significance of tumor associated tissue eosinophilia
in nasopharyngeal carcinoma. Cancer 1996; 77: 436–40.
15. van Driel WJ, Kievit-Tyson P, van den Broek LC, et al.
Presence of an eosinophilic infiltrate in cervical squamous
carcinoma results from a type 2 immune response. Gynecol
Oncol 1999; 74: 188–95.
16. Flamm J. Tumor-associated tissue inflammatory reaction and
eosinophilia in primary superficial bladder cancer. Urology
1992; 40:180- 5.
17. Marusić Z, Cupić H, Kruslin B, et al. Tumor-associated tissue
eosinophilia and inflammation in pTa and pT1 papillary
urothelial carcinoma of the bladder. Anal Quant Cytol Histol
2009; 31:239- 41.
18. Dworák O, Janssen D. Tumor-associated tissue eosinophilia in
the urinary bladder: is it a real relationship? . Appl Pathol 1989;
7: 294.
19. Huland E, Huland H. Tumor-associated eosinophilia in
interleukin-2-treated patients: evidence of toxic eosinophil
degranulation on bladder cancer cells. J Cancer Res Clin Oncol
1992; 118:463–7.
20. Lowe D, Fletcher CD, Gower RL. Tumour-associated
eosinophilia in the bladder. J Clin Pathol 1984; 37: 500- 2.

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