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RENAL GREFT FONKSİYONU ve BAZAL GLOMERULER ALAN

RENAL ALLOGRAFT FUNCTION AND BASELINE GLOMERULAR AREA

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 2001

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Measurement of glomerular area and volume have been studied for native kidney biopsies, but much less for renal transplant biopsies. Relationship of histopathological findings of zero hour biopsies with baseline glomerular area (BGA) and BGA with post transplant creatinine values have not been studied much. In this study, we have searched correlation of baseline glomerular area of 40 living related renal transplant case with post transplant creatinine values of baseline, l", 6" month and 1" and 2'" year. At the same time we have studied correlation of donor age, histopathological total scores (TS) and percentage of glomerulosclerosis (PGS) with BGA. There was no correlation between BGA and post transplant creatinine values, age, TS and PGS. Donor age was correlated with all creatinine values, PGS and TS. TS was corelated with baseline, 1st and 6st months creatinine values and PGS. PGS was correlated with all creatinine values. Average creatinine values, TS, PGS of donors elder than 50 were significantly higher but for BGA there was no significant difference. There was no significant findings for creatinine values, BGA, TS, PGS between male and female groups. Measurement of BGA in the biopsies during the transplantation or after the transplantation may be valuable for determination of graft function. In this study we didn'tfind any correlation between BGA and post transplant creatinine values, TS and PGS. In the follow up biopsies, it may be valuable to study the correlation of changes in glomerular area and the graft function.
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Abstract (Original Language): 
Glomerüler alan ve hacim ölçümü nativ böbreklerde sık renal transplant olgularında az çalışılmıştır. Sıfır saat biyopsilerde bulunan histopatolojik bulguların glomerüler boyut ile ilişkisi ve bazal glomerüler boyutun post transplant dönemde kreatinin değerleri ile ilişkisi çok araştırılmamış konulardandır. Bu çalışmada merkezimizde canlıdan renal transplantasyon yapılan 40 olguda bazal glomerüler alan (BGA) ortalamalarının bazal, birinci ve altıncı ay, birinci ve ikinci yıl kreatinin değerleriyle ilişkisi araştırıldı. Aynı zamanda BGA ile verici yaşı, histopatolojik toplam skor (TS) ve glomerüloskleroz (GS) yüzdesi ilişkisi araştırıldı. BGA ile post transplant kreatinin değerleri, yaş, TS ve GS yüzdesi arasında bir ilişki bulunmadı. Verici yaşı; tüm kreatinin değerleri, GSyüzdesi, TS ile, TS; bazal, birinci ve altıncı ay kreatinin değerleri ve GS yüzdesi ile, GS yüzdesi; tüm kreatinin değerleri ile korele idi. Elli yaşın üzerindeki vericilerde kreatinin değerleri, TS ve GS yüzdesi anlamlı olarak yüksekti, ortalama BGA için anlamlı fark bulunmadı. Erkek ve kadın vericiler arasında kreatinin değerleri, BGA, TS ve GS yüzdesi istatistiksel olarak anlamlı farklılık göstermedi. Transplant sırasında veya sonrasındaki biyopsilerde BGA ölçümleri greft fonksiyonu açısından değerli bilgiler taşıyabilir. Bu çalışmada BGA ile post transplant kreatinin değerleri, TS ve GS 'un korelasyonu saptanmadı. Takip eden biyopsilerde glomerüler boyut değişimlerinin birbiri ve greft fonksiyonu ile korelasyonunun araştırılması değerli olabilir.
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  • 1
19-26
  • Turkish

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