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A PROTECTIVE STUDY OF ETHANOLIC EXTRACT OF PORTULACA QUADRIFIDA LINN. ON PARACETAMOL INDUCED HEPATOTOXIC RATS

Journal Name:

  • Advance Research in Pharmaceuticals and Biologicals

Publication Year:

  • 2014

Key Words:

Author Name
Abstract (2. Language): 
The ethanolic extract of Portulaca quadrifida Linn. (Portuleacea) aerial parts were investigated for any in vitro and in vivo antioxidant and hepatoprotective effects. Ethanolic extract of Portulaca quadrifida (EPQ) was prepared and acute toxicity study was carried out to fix the dose. Different groups of animals (Albino rats) were administered with paracetamol (500 mg/kg, PO, once in a day for 7 days). EPQ at the dose of 300 mg/kg/day and Silymarin at 25 mg/kg/day were administered to the paracetamol treated rats for seven days. The effects of EPQ and Silymarin on serum transaminases (SGOT, SGPT), alkaline phosphatase (ALP), bilirubin (Direct and Total), cholesterol (HDL and Total) and total protein were measured in the paracetamol-induced hepatotoxic rats. Further, the effects of the extract on lipid peroxidation (LPO), glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) were estimated. EPQ and Silymarin produced significant (p < 0.05) hepatoprotective effect by decreasing the activity of serum enzymes, bilirubin, total cholesterol and in vivo lipid peroxidation and significantly (p < 0.05) increasing the levels of GSH, SOD, CAT and HDL cholesterol. From these results, it was suggested that EPQ could protect the liver cells from paracetamolinduced liver damage perhaps, by its antioxidative effect on hepatocytes, hence eliminating the deleterious effects of toxic metabolites of paracetamol.
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