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PROTECTIVE EFFECT OF PHYLLANTHUS FRATERNUS WEB ON CISPLATIN AND GENTAMICIN INDUCED NEPHROTOXICITY IN RATS

Journal Name:

  • Advance Research in Pharmaceuticals and Biologicals

Publication Year:

  • 2012

Key Words:

Author Name
Abstract (2. Language): 
The investigation of Nephroprotective activity of plant Phyllanthus fraternus (PF) Web, euphorbiaceae aerial parts extract (70% methenolic) was tested against cisplatin (anti cancer agent) and gentamicin (amino glycoside antibiotics) induced nephrotoxicity in rats. The degree of protection was determined by estimating blood urea nitrogen (BUN), serum Creatinine (Scr) levels and initial and final body weight (BW) of the animals was determined. The treatment with 70% methanolic extracts of PF at doses 100 and 200 mg/kg body weight markedly reduced cisplatin and gentamicin induced elevation of serum nitrogen and creatinine levels and normalizes body weight of the animals. The comparative histopatholigcal study of kidneys exhibited almost normal architecture as compared to control group.
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  • 3
254-258
  • English

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