Journal Name:
- The International Journal of Pharmaceutical Research and Bio-Science
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Abstract (2. Language):
Drugs are used in the prevention and treatment of symptoms and diseases but the drug-drug interactions are one of the major problems in multi-drug therapy. Beta blockers are commonly used in the treatment of hypertension in diabetic patient. Literature showed that risk of retinopathy and cardiovascular disease are more in diabetic hypertensive patients, which may cause morbidity and mortality. Therefore present study was undertaken to understand the effects of atenolol and nebivolol alone and combination with glipizide in normal and diabetic rats. The study was conducted on healthy albino andstreptozotocin induced diabetic rats. Diabetes was induced by single i.p. injection of STZ (60mg/kg) administration. The hypoglycemic effects of atenolol, nebivolol and glipizidealone and in combination were tested. Results showed that atenolol and glipizide did not have any significant effect on glucose levels on alone administration. Though repeated administration of atenolol followed by glipizide enhances hypoglycemic effect of glipizide up to one hour followed reduced hypoglycemic effect of glipizidethroughout the study period in normal animals but potentiated the hypoglycemic effect of glipizide on diabetic animals. However, nebivolol does not alter antidiabetic activity of glipizide. Hence study suggested that the dose and/or frequency of atenolol administration have to be readjusted accordingly when glipizide and atenolol need to be used concomitantly. Nebivolol is safe drug in patients having diabetes and hypertension than atenolol.
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