Journal Name:
- Indian Journal of Basic & Applied Medical Research
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Abstract (2. Language):
Introduction: NSAIDS are most widely used analgesics with established gastrointestinal side effects which may even lead
to death of the patient when used regularly. Many studies are suggestive of additional toxicities including cardiovascular and
hepatocellular toxicities. The present study was planned to compare the hepatotoxic effects of Aceclofenac and Celecoxib on
Wistar albino rats.
Methods: The animals were administered with the drugs intraperitoneally for a period of 30 days. After the study period, the
rats were sacrificed and blood samples and liver were collected. The liver was stained with H/E stain and observed under
light microscope for histopathological changes. The levels of serum AST and ALT were measured.
Observation: It was observed that the histological changes were more pronounced in case of animals treated with Celecoxib
than those treated with Aceclofenac. There was increase in the AST and ALT levels in both the experimental animal groups
when compared to control group but the increase is not significant.
Result: The histological changes are more pronounced in case of animals treated with Celecoxib than those treated with
Aceclofenac.
Conclusion: It is inferred that the chronic intake or utilization of higher doses of Celecoxib and Aceclofenac will lead to
fatty liver changes, hepatitis and other hepatic complications and Celecoxib is more hepatotoxic than Aceclofenac in
therapeutic doses.
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