You are here

Home » Content

Glycaemic and Haematological Indices of Mucuna Pruriens Seeds on Albino Rats

Journal Name:

  • International Journal of Science and Engineering Investigations

Publication Year:

  • 2017

Key Words:

Author NameFaculty of Author
Abstract (2. Language): 
The effect of ethanolic extract from seeds of Mucuna pruriens (1000mg/kg and 500mg/kg) on blood glucose in glucose-dosed rats was investigated. The effect of prolonged administration of the extract on haematological parameters was also assayed. The extract and reference drugs were administered orally. Blood glucose concentration was monitored at intervals. Haematological analysis on whole blood revealed a significant (p<0.05) reduction in PCV, RBC, platelets and haemoglobin levels for the group treated with 1000mg/kg extract. (20.30±2.70, 4.88±6.76, 12.30±59.00 and 6.45±1.05) when compared to the control group (29.80±3.58, 3.52±4.65, 32.60±14.90 and 9.96±1.31). A significant reduction in blood glucose level of 52.3% and 45.5% in the treatment group were achieved. These suggest that high dose of the extract though effective in glycaemic control could suppress the haemopoietic system on prolong usage.
Bookmark/Search this post with
FULL TEXT (PDF): 
PDF icon arastirmax-glycaemic-and-haematological-indices-mucuna-pruriens-seeds-albino-rats.pdf
  • 4
1
3
  • English

REFERENCES

References: 

1] Adepoju, G.K.A. and Odubene, O.O. (2009). Effect of Mucuna pruriens on some Haematological and Biochemical Parameters. Journal of Medicinal Plant Resources, 3(2): 73-76.
[2] Akindele, O.A., Babatunde, A.I., Chinedu, F.M., Samuel, O.A., Oluwasola, C.A., and Oluseyi, A.A. (2012). Rat model of food induced non-obese-type 2 diabetes mellitus; comparative pathophysiology and histopathology. International Journal of Physiology, Pathophysiology and Pharmacology. 4(1):51-58.
[3] American Diabetes Association (2001). Postprandial Blood Glucose (Review). Diabetes Care, 24:775-778.
[4] Arowosegbe, S., Olanipekun, M. K. and Kayode, J. (2015). Ethnobotanical Suvery of Medicinal Plants Used for the Treatment of Diabetes Mellitus in Ekiti South South Senatorial District, Nigeria. European Journal of Botany, Plant Sciences and Physiology 2(4): 1-8.
[5] Cerillo, A. (2005). Postpriandial Hyperglycaemia and Diabetes Complications. Is it time to treat? Diabetes, 54(1):1-7.
[6] Colak, S., Geyikoghu, F., Asian, A., Deniz, GY. (2012). Effects of Lichen extracts on haematological parameters of rats with experimental insulin-dependent diabetes mellitus. Toxicology and Industrial Health.
[7] Etuk, E. U., and Mohammed, B. J. (2009). Informant Consensus Selection Method: A Reliability on Medicinal Plants Used in North Western Nigeria for the Treatment of Diabetes Mellitus. African Journal of Pharmacy and Pharmacology 3(10): 496-500.
[8] Ganong, W.F. (1999). A Review of Medical Physiology. Appleton and Lange, Standford, USA pp 187-241.
[9] Guerranti, R., Aguiyi, J.C., Neri, S., Leoncini, R., Pagani, R., Marinello, E. (2002). Proteins From Mucuna pruriens and Enzymes from Echis cariatus Venom: Characterization and Cross-reactions. Journal of Biological Chemistry 10; 277 (19): 17072-8.
[10] McLellan., S.A., McLellan, D.B..L, Walsh, T.S. (2003). Anaemia and Red Blood Cell Transfusion in Critically ill Patient. Blood Reviews 17:195-208.
[11] Misra., L., Wagner H (2007). Extraction of bioactive principle from Mucuna pruriens seeds. Indian Journal of Biochemistry and Biophysics 44:56–60.
[12] Olaboro, G. (1993). Amino acid, Mineral, Trypsin Inhibitor and Proximate Analyses of Velvet Beans and Bean Fractions. Discovery and innovation 5(2): 163-166.
[13] Sule, O.J., Elekwa, I., Ayalogu, E.O. (2012). Effect of Acalypha wilkesiana Muell Arg. in Haematological Parameters in Wistar Rats. International Journal of Biological and Medical Research 3: 1234-1237.
[14] Sunmonu, T.O., Oloyele, O.B. (2010). Performance and Haematological Indices in Rats Exposed to Monocrotophos Contamination. Human and Experimental Toxicology 29(10): 845-850.

Thank you for copying data from http://www.arastirmax.com