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ETHOSOMES -A PHYTO DRUG DELIVERY SYSTEM

Journal Name:

  • Advance Research in Pharmaceuticals and Biologicals

Publication Year:

  • 2012

Key Words:

Author Name
Abstract (2. Language): 
Ethosomes are the ethanolic phospholipid vesicles which are used mainly for transdermal delivery of drugs. Ethosomes are soft, malleable vesicles tailored for enhanced delivery of active agents. Ethosomes have higher penetration rate through the skin as compared to liposomes hence these can be used widely in place of liposomes. The increased permeation of ethosomes is probably due to its ethanolic content. Ethanol increases the cell membrane lipid fluidity which results in increased skin penetrability of the ethosomes. These ethosomes permeates inside the skin and fuse with cell membrane lipids and release the drug. Hot and cold methods are used for formulation of ethosomes. Evaluation parameters include size, shape, drug content, zeta potential etc. Ethosomes have been successfully evaluated for the delivery of many drugs for e.g. Cyclosporine A, insulin, salbutamol, trihexyphenidil, etc. Ethosomes provides a number of important benefits including improving the drug’s efficacy, enhancing patient compliance and comfort and reducing the total cost of treatment. Ethosomes can be important drug delivery tool in the future.
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REFERENCES

References: 

1. D. D. Verma, A. Fahr. Synergistic
penetration effects of ethanol and
phospholipids on the topical delivery
of Cyclosporin A, J. Control Release,
97: 55‐66 (2004).
2. M. K. Bhalaria, S. Naik, A. N. Misra.
Ethosomes: A novel delivery system
for antifungal drugs in the treatment of
topical fungal diseases, Ind. J. of
Experi. Biol. 47: 368-375 (2009).
3. S. Patel. Ethosomes: A promising tool
for transdermal delivery of drug,
Pharma Info.Net, 5(3) (2007).
4. E. Touitou, M. Alkabes, N. Dayan, M.
Eliaz. Pharm. Res.14, S305-S306
(1997).
5. E. Touitou, N. Dayan, L. Bergelson, F.
Levi-Scaffer, A. Pilponsky. (1998) J.
Lipid Res. 8: 113-114 (1998).
6. B. Godin, and E. Touitou. Crit. Rev.
Therp. Drug Carrier Sys, 20(1): 63-102
(2003).
7. E. Touitou. Composition of applying
active substance to or through the skin,
US patent, 5,716,638, 1996.
8. E. Touitou, Composition of applying
active substance to or through the skin,
US patent, 5, 540,934, 1998.
9. S. Jain, A. K. Tiwary, N. K. Jain.
Sustained and targeted transdermal
delivery of an anti-HIV agent using
elastic liposomal formulation:
Mechanism of action, Current Drug
Delivery 3(2): 157-164 (2006).
10. E. Horwitz, S. Pisanty, R. Czerninsky,
M. Helser, E. Eliav, E. Touitou. Oral
Surg Oral Pathol Oral Radiol Endod,
88: 700-05 (1999).
DIPAL et al., ARPB, 2012; Vol 2 (1) ISSN 2250-0774
(Review Article)
www.arpb.info Page 8
11. A. K. Banga, and Y. W. Chein.
Hydrogel-based iontotherapeutic
delivery devices for transdermal
delivery of peptides/protein drugs
Pharm. Res. 10: 697-702 (1993).
12. N. Dayan, E. Touitou. Carriers for skin
deliveryof trihexyphenidyl HCl:
Ethosomes vs. Liposomes
Biomaterials. 21, 1879-1885 (2000).
13. E. Touitou. Composition and methods
for intracellular delivery,
PCT/IL02/00516, 2002.
14. M. Lodzki, B. Godin, L. Rakou, R.
Mechoulam, R. Gallily, E. Touitou.
Ethosomes: A recent approach in
transdermal/ topical delivery, J.
Control. Release 93: 377-387. (2003).
15. B. Godin, E. Touitou. Mechanism of
bacitracin permeation, J. Control
Release. 187, 1-15 (2004).
16. S. Jain, R. B. Umamaheshwari, D.
Bhadra, N. K. Jain. Ethosomes-A
novel transdermal delivery of an anti-
HIV agent, Ind. J. Pharm. Sci. 66 (1):
72-81 (2004).
17. E. Esposito, E. Menegatti, R. Cortesi.
Ethosomes and liposomes as topical
vehicles for azelaic acid: a
preformulation study. J. Cosmet. Sci.
55 (3): 253-64 (2004).
18. D. Paolino, G. Lucania, D. Mardente,
F. Alhaique, M. Fresta. Ethosomes for
skin delivery of ammonium
glycyrrhizinate: in vitro percutaneous
permeation through human skin and in
vivo anti-inflammatory activity on
human volunteers, J. Control. Release
106: 99-110 (2005).

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