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ETHOSOMES: A NOVEL DRUG CARRIER FOR TRANSDERMAL DRUG DELIVERY

Journal Name:

  • The International Journal of Pharmaceutical Research and Bio-Science

Publication Year:

  • 2012

Key Words:

Author Name
Abstract (2. Language): 
Skin acts as a major target as well as a principal barrier for topical/transdermal drug delivery. Despite the many advantages of this system, the major obstacle is the low diffusion rate of drugs across the stratum corneum. Several methods have been tried to increase the permeation rate of drugs temporarily. One simple and convenient approach is application of drugs in formulation with elastic vesicles or skin enhancers. Vesicular system is one of the most controversial methods for transdermal delivery of active substances in that ethosome are the ethanolic phospholipids vesicles which are used mainly for transdermal delivery of drugs. Ethosomes have higher penetration rate through skin due to its ethanolic content. In this article reviews various aspect of ethosomes including their mechanism of penetration, preparation, advantages, characterization, composition, preparation, application and marketed product. These carriers open new challenges and opportunities for the development of novel improved therapies. Ethosomes are noninvasive delivery carriers that enable drugs to reach the deep skin layers and/or the systemic circulation. Although ethosomal systems are conceptually sophisticated, they are characterized by simplicity in their preparation, safety, and efficacy a combination that can highly expand their application. Ethosomes are soft, malleable vesicles tailored for enhanced delivery of active agents. This article reviews various aspects of ethosomes including their preparation, characterization, potential advantages and their applications in drug delivery. Because of their unique structure, ethosomes are able to encapsulate and deliver through the skin highly lipophilic molecules such as cannabinoids, testosterone, and minoxidil, as well as cationic drugs such as propranolol, trihexyphenidil, Cyclosporine A, insulin, Salbutamol etc. Ethosomes provides a number of important benefits including improving the drug's efficacy, enhancing patient compliance and comfort and reducing the total cost of treatment. Enhanced delivery of bioactive molecules through the skin and cellular membranes by means of an ethosomal carrier opens numerous challenges and opportunities for the research and future development of novel improved therapies.
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REFERENCES

References: 

1. Touitou E inventor: Composition of 2. Patel S: Ethosomes: A promising tool for
applying active substance to or through the transdermal delivery of drug, Pharma
skin. US patent 5 540 934. July 30, 1996. Info.Net. 2007; 5(3).
Available Online At www.ijprbs.com
Review Article
Pooja Verma, IJPRBS, 2012; Volume 1(6): 1-9
3. Touitou E, Dayan N, Bergelson L, Godin B and Eliaz M: Ethosomes novel vesicular carriers for enhanced delivery: characterization and skin penetration properties, J Control Release. 2000; 65: 403-418.
4. Touitou E inventor: Composition of applying active substance to or through the skin. US patent 5 716 638. October 2, 1998.
5. Touitou E, Godin B, Dayan N, Weiss C, Piliponsky A and Levi- Schaffer F: Intracellular delivery mediated by an ethosomal carrier. Biomaterials. 2001; 22:
3053-3059.
6. Jain S, Umamaheshwari RB, Bhadra D and Jain NK: Ethosomes: a novel vesicular carrier for enhanced transdermal delivery of an anti-HIV agent, Ind J Pharma Sci. 2004;
66: 72-81.
7. Size determination of liposomes, Liposomes-A practical approach, edited by RRC New (Oxford University Press, New York) 1990: 154.
8. Heeremans JLM, Gerristen HR, Meusen SP, Mijnheer FW, Gangaram RS, Panday G, Prevost R, Kluft C and Crommelin DJA: The preparation of tissue type plasminogen
ISSN: 2277-8713
IJPRBS
activator (t- PA) containing liposomes: entrapment efficacy and ultracentrifugation damage, J Drug Target. 1995; 3: 301.
9. Preparation of liposomes and size determination, Liposomes-A practical approach, edited by RRC New (Oxford University Press, New York) 1990: 36.
10. Touitou E, Dayan N, Levi-Schaffer F and Piliponsky A: Novel lipid vesicular system for enhanced delivery, J Lip Res. 1998; 8: 113.
11. Asbill CS, El-Kattan AF and Michniak B
Enhancement of transdermal drug delivery: chemical and physical approaches, Crit Rev Therapeut Drug Carrier Sys, 17, 2000, 621.
12. Verma, DD and Fahr A: Synergistic penetration effects of ethanol and phospholipids on the topical delivery of Cyclosporin A, J. Control Release. 2004; 97: 55-66.
13. Bhalaria MK, Naik S and Misra AN: Ethosomes: A novel delivery system for antifungal drugs in the treatment of topical fungal diseases, Indian Journal of Experimental Biology. 2009; 47: 368-375.
14. Guo J, Ping Q, Sun G and Jiao C: Lecithin vesicular carriers for transdermal delivery of
Available Online At www.ijprbs.com
Review Article
Pooja Verma, IJPRBS, 2012; Volume 1(6): 1-9
ISSN: 2277-8713
IJPRBS
cyclosporine A, Int. J. Pharm. 2000; 194(2):
201-207.
15. Maghraby GMM, Williams AC and Barry BW: Oestradiol skin delivery from ultra deformable liposomes: refinement of surfactant concentration, Int. J. Pharm.
2000; 196(1): 63-74.
16. Fry DW, White JC, and Goldman ID,
Rapid secretion of low molecular weight solutes from liposomes without dilution. Anal. Biochem. 1978; 90: 809-815.
17. Cevc G, Schatzlein A and Blume G: Transdermal drug carriers: Basic properties, optimization and transfer efficiency in case of epicutaneously applied peptides, J. Control. Release. 1995; 36: 3-16.
18. Vanden Berge BAI, Swartzendruber VAB and Geest J: Development of an optimal protocol for the ultrastructural examination of skin by transmission electron microscopy,
J. Microsc. 1997; 187(2): 125-133.
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