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DİETLE ALINAN KURŞUNUN ERİTROSİT OSMOTİK DİRENÇ VE KAN VİSKOZİTESİNE ETKİLERİNİN ARAŞTIRILMASI

Journal Name:

  • Cerrahpaşa Tıp Dergisi

Publication Year:

  • 2000

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
In this study, the effect of lead concentration on blood viscosity and erythrocyte osmotic resistance were tried to be investigated in rats. Design.- Fourteen Wistar-Albino type female rats were picked and animals were divided into two as control and experimental groups. Nutrition’s type and content of both groups was same. But lead acetate was added to the drinking water of experimental group for four weeks. At the end of fourth week, blood samples were drawn from abdominal aorta of rats. Blood viscosity and erythrocyte osmotic fragility were determined. Results.- While increase in blood lead concentration values of experimental group was detected, the osmotic resistance and blood viscosity values were found to be decreased according to the same parameters of control group. Conclusion.- Our study indicated that the intake of lead through the drinking water leads to reduce of blood viscosity and osmotic resistance of erythrocytes.
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Abstract (Original Language): 
Bu çalışmamızda diet ile alınan kuşunun kan viskozitesi ve eritrosit osmotik direnci üzerine etkisi araştırılmıştır. Bu amaçla 14 Wistar Albino türü dişi sıçan kontrol ve deney grubu olmak üzere iki gruba ayrıldı. Deney süresince her iki grup aynı tür katı yem ile beslenirken deney grubu sıçanlarının içme suyuna kurşun asetat katıldı. Dört hafta süren deney sonunda abdominal aortadan alınan kan örneklerinde kan kurşun konsantrasyonlar ı ölçümü, kan viskozitesi ve osmotik direnç tayini yapıldı. Deney grubu sıçanlarda kan kurşun konsantrasyonlarının kontrollere göre artt ığı, maksimal ve minimal osmotik direnç- te anlamlı azalma olduğu ve kan viskozitesi değerlerinin kontrol değerlerine göre anlamlı olarak azaldığı saptandı. Bulgularımız içecek ile alınan kurşunun eritrositlerin osmotik direncini azalttığını, olasılıkla sferosit yapı oluşumu ile osmotik frajilite de artış olduğunu göstermiştir. Ayrıca kurşunun kan viskozitesini de azalttığı ve kan kurşun konsantrasyonunu arttırdığı saptanmıştır.
FULL TEXT (PDF): 
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  • 3
129-133
  • Turkish

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