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Nefrolitiazisli Hastalarda 24 Saatlik İdrar ve Serum Parametreleri Arasında İlişki

Relationship Between 24-Hour Urine and Serum Parameters in Patients with Nephrolithiasis

Journal Name:

  • Fırat Tıp Dergisi

Publication Year:

  • 2007

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Objective: Nephrolithiasis is a common disease, whereas the mechanisms by which stones develop in the kidney are poorly understood. While high levels of oxalate, uric acid, calcium, and phosphate in the urine increase the formation of nephrolithiasis, increased urinary excretion of citrate, magnesium, albumin and alkali urine decrease this process. In this study, we aimed to identify the possible relationship between some serum and 24¬hour urinary parameters in patients with nephrolithiasis. Materials and Methods: Two hundreds thirty-one patients with nephrolithiasis (aged 18-65 years; 143 men, 88 women) were retrospectively examined in this study. Results: Significant correlations observed between urine and serum levels of creatinine with urine and serum levels of uric acid [r= 0.70, (p<0.01) for urine; r= 0.55, (p<0.01) for serum]; urine levels of phosphorus with urine levels of urea (r= 0.998, p<0.01); urine levels of uric acid with urine levels of calcium (r= 0.488, p<0.001) and between urine levels of chlorine and uric acid (r= 0.547, p=0.00) and creatinine (r= 0.59, p<0.001). Conclusion: In conclusion, there are some correlations between the values of urine and serum parameters. In patients with nephrolithiasis, 24-hour urine analysis may be helpful for the assessment of stone formation and development. Furthermore these correlations may conduct clinicians determine better treatment strategies. ©2007, Firat University, Medical Faculty
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Abstract (Original Language): 
Amaç: Nefrolitiazis yaygın bir hastalık olmasına rağmen, böbrekteki taş oluşum mekanizması tam olarak anlaşılamamıştır. İdrarda yüksek konsantrasyonda oksalat, ürik asit, kalsiyum ve fosfor bulunması nefrolitiazis oluşma riskini arttırırken; sitrat, magnezyum, albumin düzeylerinin yüksekliği ve idrarın alkali olması ise bu riski azaltmaktadır. Bu çalışmada nefrolitiasizli hastalarda serum ve 24 saatlik idrar analizi sonucu elde edilen parametreler arasındaki muhtemel ilişkiyi tespit etmeyi amaçladık. Gereç ve Yöntem: 231 adet nefrolitiazisli hasta (18-65 yaşları arasında; 143 erkek, 88 kadın)retrospektif olarak incelendi. Bulgular: İdrar ve serum kreatinin değerleri ile idrar ve serum ürik asit değerleri arasında [sırasıyla r= 0.70, (p<0.001); r= 0.55, (p<0.001)]; idrar fosforu ile idrar üre değerleri arasında (r= 0.998, p<0.001); idrar ürik asiti ile idrar kalsiyum değerleri arasında (r= 0.488, p<0.001); idrar klor değerleri ile hem idrar ürik asi hem de idrar kreatinin değerleri arasında [sırasıyla r= 0.547, (p=0.00);r= 0.59, (p<0.001)] istatiksel olarak anlamı korelasyon bulundu. Sonuç: Bazı serum ve idrar parametreleri arasında korelasyon vardır. Nefrolitiazisli hastalarda taş oluşumu mekanizmasının daha iyi anlaşılması açısından 24 saatlik idrar analizi faydalı olabilir. Dahası bu korelasyonlar hastaya klinik yaklaşımı yönlendirebilir ve tedavi protokolünü etkileyebilir. ©2007, Fırat Üniversitesi, Tıp Fakültes
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  • Turkish

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