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Akut mezenterik iskemide plazma sitokin düzeylerinin tanısal değeri: deneysel bir çalışma

Diagnostic value of plasma cytokine levels in acute mesenteric ischemia: an experimental study

Journal Name:

  • Gülhane Tıp Dergisi

Publication Year:

  • 2007

Key Words:

Keywords (Original Language):

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Abstract (2. Language): 
Frequency of mortality in patients with superior mesenteric artery occlusion is still high due to difficulties in current diagnosis. The initial symptoms of acute intestinal ischemia is non-specific and indistinguishable from acute abdomen. Regardless of the etiology, the time interval between diagnosis and therapy determines the prognosis of acute intestinal ischemia. Our purpose in this study was to compare serum leukocyte levels and cytokine gradients to evaluate their prognostic values in the early diagnosis of acute intestinal ischemia. In this study 80 rats were divided into 4 groups as control, laparatomy, strangulation, and superior mesenteric artery occlusion groups. Serum IL-1β, IL-6 and TNFα and blood leukocyte levels were measured and the resected intestinal specimens were histopathologically evaluated for intestinal ischemia and tissue necrosis. The results showed an increase in cytokine levels in parallel with tissue ischemia. We believe that, although not specific for intestinal ischemia, serum IL-1β, IL-6 and TNFα levels may be used as an early indicator of intestinal ischemia if rapid analysis techniques are developed.
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Abstract (Original Language): 
Süperiyor mezenterik arter oklüzyonlu hastalardaki mortalite oranları, mevcut tanı yöntemlerindeki zorluğa bağlı olarak hala yüksektir. Akut intestinal iskeminin başlangıç bulguları özgün değildir ve akut abdomenden ayırmak zordur. Etiyolojiden bağımsız olarak, tanı ve tedavi arasındaki süre akut intestinal iskeminin prognozunu belirler. Bu çalışmada amacımız serum lökosit düzeyleri ile sitokin düzeylerini karşılaştırarak, bunların akut intestinal iskeminin erken tanısındaki tanısal önemini değerlendirmektir. Çalışmada 80 rat; kontrol, laparatomi, strangülasyon ve süperiyor mezenterik arter oklüzyonu grupları olarak 4 gruba ayrıldı. Serum IL-1β, IL-6, TNFα ve kan lökosit düzeyleri ölçüldü ve rezeke edilen barsaklar intestinal iskemi ve doku nekrozu açısından histopatolojik olarak değerlendirildi. Sonuçlar doku iskemisine paralel olarak sitokin değerlerinde yükselme gösterdi. İntestinal iskemiye spesifik olmamakla birlikte, serum IL-1β, IL-6 ve TNFα değerlerinin, daha hızlı analiz yöntemleri geliştirilirse, intestinal iskeminin erken göstergesi olarak kullanılabileceğini düşünüyoruz.
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  • 4
216-221
  • English

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