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Sarkoidozlu hasta sonuçlarımız

Results of our patients with sarcoidosis

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Abstract (2. Language): 
A total of 34 patients with sarcoidosis diagnosed and followed-up between 2002 and 2007 were retrospectively investigated. Of the patients 9 (26.4%) were female and 25 (73.5%) were male. The most common complaints were dyspnea (58.8%), cough (47.1%) and chest pain (29%). Of all the patients 8 (23.5%) were in stage I, 23 (67.6%) in stage II and 3 (8.8%) in stage III. Eighteen patients (52.9%), 9 patients (26.4%), 4 patients (11.7%), 2 patients (5.8%) and one patient (2.9%) were diagnosed with transbronchial lung biopsy, mediastinoscopy and lymph node biopsy, transbronchial needle aspiration biopsy, open lung biopsy, and clinically, respectively. Erythema nodosum in 4 patients (11.7%), nephrolithiasis in 3 patients (8.82%), liver involvement in 1 patient (2.94%) and ocular involvement in 1 patient (2.94%) were detected as extrapulmoner manifestations. Atypical parenchymal radiological findings were detected in 6 (17.6%) of the patients, and the indication of systemic steroid treatment was determined in 18 (52.9%) of the patients. Our results in patients with sarcoidosis were in accordance with the literature findings, most of the patients were diagnosed with transbronchial lung biopsy and mediastinoscopy, and atypical radiological findings were detected in a significant extent.
Abstract (Original Language): 
Sarkoidoz tanısı konarak 2002 ile 2007 yılları arasında izlenen 34 hasta retrospektif olarak incelendi. Hastaların 9’u kadın (%26.4), 25’i erkekti (%73.5). En sık şikayetler ise nefes darlığı (%58.8), öksürük (%47.1) ve göğüs ağrısıydı (%29). Hastaların 8’i (%23.5) evre I, 23’ü (%67.6) evre II, 3’ü (%8.8) evre III olarak değerlendirildiler. On sekiz (%52.9) hastaya transbronşiyal akciğer biyopsisi, 9 (%26.4) hastaya mediyastinoskopi ve lenf nodu biyopsisi, 4 (%11.7) hastaya transbronşiyal iğne aspirasyon biyopsisi, 2 (%5.8) hastaya açık akciğer biyopsisi ve 1 (%2.9) hastaya klinik olarak tanı konmuştu. Ekstrapulmoner tutulum olarak 4 hastada eritema nodozum (%11.7), 3 hastada nefrolitiyazis (%8.82), 1 hastada karaciğer tutulumu (%2.94) ve 1 hastada göz tutulumu (%2.94) tespit edildi. Hastaların 6’sında (%17.6) atipik parankimal radyolojik bulgu tespit edildi ve toplam 18 hastada (%52.9) sistemik steroid tedavisi endikasyonu saptandı. Sarkoidozlu hasta sonuçlarımız literatür bilgileri ile uyumlu bulunmuş olup, olguların büyük kısmına transbronşiyal akciğer biyopsisi ve mediyastinoskopi ile tanı konmuştur ve önemli bir oranda da atipik radyolojik bulgular tespit edilmiştir.
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REFERENCES

References: 

Kaynaklar
1. Nunes H, Bouvry D, Soler P, Valeyre D. Sarcoidosis
(review). Orphanet J Rare Dis 2007; 2: 46-53.
2. Kumbasar Ö. Sarkoidoz. Solunum 2008; 10: 9-18.
3. Karalezli A, Ünsal M, Gündoğdu C, Dursun G, Başer
Y. Sarkoidozlu 50 olgunun değerlendirilmesi. Türkiye
Klinikleri Tıp Bilimleri Dergisi 1998; 18: 245-254.
4. Aytemur AZ, Erdinç M, Erdinç E, Ateş H, Akyürekli Ö.
Sarkoidozda evrelere göre klinik özellikler ve tanısal
yaklaşım. Tuberk Toraks 2003; 51: 11-16.
5. Yalnız E, Kömürcülüğü A, Polat EG, Utkaner G, Yüksel
M. Sarkoidozda klinik, radyolojik, laboratuvarla ilgili
parametreler ve tanı. Toraks 2003; 4: 48-52.
6. Tabak L, Kılıçarslan Z, Kıyan E ve ark. 147 Sarkoidoz
hastasının klinik özellikleri. Solunum 2001; 3: 80-85.
7. Çetinkaya E, Yıldız P, Kadakal F, Altın S, Poluman A,
Yılmaz V. Sarkoidozda klinik, laboratuvar, fonksiyonel
parametreler ve prognoz. Solunum 2001; 12: 284-288.
8. Sharma SK, Mohan A, Guleria JS, et al. Clinical
characteristics, pulmonary function abnormalities and
outcome of prednisolone treatment in 106 patients with
sarcoidosis. J Assoc Physicians India 2001; 49: 697-704.
9. Baran A, Özşeker F, Güneylioğlu D ve ark. Sarkoidoz:
yedi yıllık deneyim. Toraks 2004; 5: 160-165.
10. Ocaklı B, Karakurt Z, Sulu E ve ark. Sarkoidozda
transbronşiyal biyopsinin yeri ve önemi. Göztepe Tıp
Dergisi 2005; 20: 168-170.
11. Trisolini R, Tinelli C, Cancellieri A, et al. Transbronchial
needle aspiration in sarcoidosis: yield and predictors of
a positive aspirate. J Thorac Cardiovasc Surg 2008; 135:
837-842.256 • Aralık 2008 • Gülhane Tıp Derg Ertuğrul ve ark.
12. Bilaçeroğlu S, Perim K, Günel O, Cağirici U, Büyükşirin
M. Combining transbronchial aspiration with
endobronchial and transbronchial biopsy in sarcoidosis.
Monaldi Arch Chest Dis 1999; 54: 217-223.
13. Uygun S, Yanardag H, Karter Y, Demirci S. Course and
prognosis of sarcoidosis in a referral setting in Turkey;
analysis of 166 patients. Acta Medica (Hradec Kralove)
2006; 49: 51-57.
14. Loddenkemper R, Kloppenborg A, Schoenfeld N,
Grosser H, Costabel U. Clinical findings in 715 patients
with newly detected pulmonary sarcoidosis-results
of a cooperative study in former West Germany and
Switzerland. WATL Study Group. Sarcoidosis Vasc
Diffuse Lung Dis 1998; 15: 178-182.
15. Rizzato G. Extrapulmonary presentation of sarcoidosis.
Curr Opin Pulm Med 2001; 7: 295-297.
16. Bottaro L, Calderan L, Dibilio D, Mosconi E, Maffessanti
M. Pulmonary sarcoidosis: atypical HRCT features and
differential diagnostic problems. Radiol Med 2004; 107:
273-285.
17. Conant EF, Glickstein MF, Mahar P, Miller WT.
Pulmonary sarcoidosis in the older patient: conventional
radiographic features. Radiology 1998; 169: 315-319
18. Grutters JC, van den Bosch JMM. Corticosteroid
treatment in sarcoidosis. Eur Respir J 2006; 28:
627-636.
19. Hunninghake GW, Costabel U, Ando M, et al. ATS/
ERS/WASOG statement on sarcoidosis. American
Thoracic Society/European Respiratory Society/World
Association of Sarcoidosis and other Granulomatous
Disorders. Sarcoidosis Vasc Diffuse Lung Dis 1999; 16:
149-173.

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