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An anatomical study: The variation of retinal nerve fiber layer thickness with age and ocular axial length in subjects of West Bengal.

Journal Name:

  • Indian Journal of Basic & Applied Medical Research

Publication Year:

  • 2013

Key Words:

Author Name
Abstract (2. Language): 
Ganglion cells form the second order neurons of the visual pathway. The Retinal nerve fibre layer (RNFL) consists of unmyelinated axons of Ganglion cells which converge at the Optic nerve head. Increasing age and increased axial length of the eyeball have been noted to cause a reduction in the RNFL thickness. The present work aims to correlate the effects of increasing age and axial length of the eyeball on the Retinal nerve fibre layer thickness in middle aged and elderly subjects of West Bengal. 380 Adults of both sexes and of various age groups , minimum age being above 40 years were chosen for the study. RNFL thickness was measured by Optical Coherence Tomography ( OCT ) . We have been able to show that RNFL thickness gradually decreases with increasing age and axial length of the eyeball. The results also show that this effect is aggravated for higher values of the independent variables , i.e, at higher decades of age and at moderate or severely increased axial length. We believe that this study will be able to enhance our knowledge regarding the anatomical and pathophysiological relation between an unique organ of our body , the organ of vision , the eye.
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REFERENCES

References: 

1. Khurana,A.K.,Khurana,Indu,Anatomy and physiology of eye, 2nd edition.:140-141:CBS
Publishers and Distributors. New Delhi and Bangalore.
2. Jacob A, Thomas R, Koshi SP, Bragama A, Muliyil J. Prevalence of primary glaucoma in an
urban South Indian population. IJO 1998;46:81-6
3. Gordon M.O. , Biese J.A. Bradt J.D. , et al. The Ocular Hypertension Treatment
Study.Baseline factors that predict the onset of primary open angle glaucoma. 2002; 120:714.
4. Huang D. [et al.] Optical Coherence Tomography [Artikel] // Science. - 1991. - 1178 : Bd.254.
5. Sony P, Sihota R, Tewari HK et al. Quantification of the retinal nerve fibre layer
thickness in normal Indian eyes with optical coherence tomography. IJO, 2004;52:303.
6. R.Ramkrishnan. Sarrabh Mittal, Sonal Ambatkar,Mohideen.A.Kader.: Retinal nerve fibre layer
thickness in normal Indian population by Optical Coherence Tomography: Indian journal of
ophthalmology 2006:54:11-5
7. Yamada H, Yamakawa Y, Chiba M, Wakakura M :Evaluation of the effect of aging on retinal
nerve fiber thickness of normal Japanese measured by optical coherence tomography :Nippon
Ganka Gakkai Zasshi. 2006 Mar;110(3):165-70.
8. Peng PH, Lin HS. Retinal nerve fiber layer thickness measured by optical coherence tomography
in non-glaucomatous Taiwanese:J Formos Med Assoc. 2008 Aug;107(8):627-34
9. Budenz . D . L. , Anderson . D.R . ,et al.Determinants of normal RNFL thickness by Stratus
OCT.Ophthalmology 2007 , june 114 (6) : 1046-52.
10. Manassakorn A, Chaidaroon W, Ausayakhun S et al. Normative database of Retinal nerve fiber
layer andMacular retinal thickness in a Thai population. Jpn J Ophthalmol. 2008;52:450-6.
11. Parikh RS, Parikh SR, Sekhar GC, Prabakaran S, Babu JG, Thomas R: Normal Age related decay
of retinal nerve fibre layer thickness:Ophthalmology. 2007;114:921-926
Indian Journal of Basic & Applied Medical Research; September 2013: Issue-8, Vol.-2, P. 968-976
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www.ijbamr.com
12.Yasser M. Tariq, Chameen Samarawickrama, Amy Pai, George Burlutskyand Paul Mitchell :Impact
of Ethnicity on the Correlation of Retinal Parameters with Axial Length iovs.10-5226Invest.
Ophthalmol. Vis. Sci.October 2010 vol. 51, no.10 4977-4982.
12. Leung CK, Mohamed S, Leung KS, Cheung CY, Chan SL, Cheng DK ,Lee A.K. Leung G Y,
Rao SK, Lam DS: Retinal nerve fibre layer measurements in Myopia: an OCT study: Invest
OphthalmolVis Sci.2006 Dec :47(12):5171-6.
13. Schweitzer KD, Ehmann D, García R. Nerve fibre layer changes in highly myopic eyes by
optical coherence tomography.: Can J Ophthalmol. 2009 , Jun;44(3):e13-6.
15. Sang Hoon Park, Ki Ho Park, Joon Mo Kim, Chul Young Choi :Relation between Axial Length
and Ocular Parameters :Ophthalmologica 2010;224: 188-193.
16. Rauscher FM, Sekhon N, Feuer WJ, Budenz DL: Myopia affects retinal nerve fiber layer
measurements as determined by optical coherence tomography.:J of Glaucoma 2009 Sep;18(7):501-
17. Hoh ST, Lim MC, Seah SK, Lim AT, Chew SJ, Foster PJ, Aung T.: Peripapillary
Retinal nerve fiber layer thickness variations with myopia:Ophthalmology. 2006
May;113(5):773-7.

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