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Sigarada bulunan bazı kimyasal maddeler ve bunların değişik organlardaki kanserojen etkileri

The cancerogen effects of some chemicals substances of tobacco in various organs

Journal Name:

  • İnönü Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 1994

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
This review summarises evidence relevant to the involvement of N-nitroso compounds in the induction of tobacco-related cancers in man. Cancers of the oral cavity, lung, oesophagus and pancreas will be discussed. Human exposure to nitrosamine compounds in tobacco products is more intense and widespread than from any other known source. Many substances, such as N-nitroso com/munds. 4-<N-nitrosomethylamino)-l-(3 pyridyl)-1-butanone and N'-nitrosonornicotine and polynuclear aromatic hydrocarbons available in tobacco may involve in causing cancers of the oral cavity, lung, oesophagus and pancreas m tobacco users. NNK and its metabolites have been shown to induce tumours in experimental animals. Both NNK and benzo[a/pyrene active the K-ras oncogenes with mutations in codon 12 were detected m 13 of 45 adenocarcinomas obtained from the lungs of smokers. The reduction or elimination of these substances from tobacco products would probably lead to a decrease m the incidence of these cancers. /Journal of Turgut Özal Afedical Center l(4):342-345,]994/
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Abstract (Original Language): 
Hu çalışma, sigaranın kanserojen etkileri ile ilgili bilimsel yayınların incelenmesi ve bunun ışığında sigara yapımında kullanılan tütün kalitesi ile ilgili uygulanabilir bazı önerilerin ortaya konması amacı ile yapılmıştır. Yapılan epıdemiyolojik çalışmalar sigara içiminin ağız, gırtlak, akciğer, ösofagus ve idrar kesesi kanserlerine sebep olabileceğini göstermektedir. Sigarada bulunan polisiklik hidrokarbonlar, N-nitrosaminler ve heterosiklik aminler muhtemel kanser yapıcı maddeler olup, deney hayvanları ve insan doku kültürü çalışmaları bunu doğrular niteliktedir. Özellikle nitrosaminler bakımından zengin olan siyah tütünün bu riski daha da artırabileceği ifade edilmiş olup polisiklik aromatik hidrokarbonlar ve N-nitroso gibi tütün orijinli olan maddelerin fare derisinde kanserine sebep olabileceği gösterilmiştir. Bu maddelerin ayrıca K-ras onkojenlerını aktif/eştirerek kodon 12'de nokta mutasyonlarma sebep olduğu bulunmuştur. Sigaranın kanser yapıcı elkisısinın azaltılabilmesi için, tütün tiplerini nitrat içeriklerine göre sınıflandırarak tütünlerde bulunan nitrat bileşiklerini düşürücü tedbirler alınması toplum sağlığı yönünden önemli görülmektedir.[Turgut Özal Tıp Merkezi Dergisi l(4):342-345.1994]
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  • 4
342-345
  • Turkish

REFERENCES

References: 

1 Duuren BL Identification of some polynuclear aromatic hydrocarbons in cigarette-smoke condensate. J Nat Cancer Inst 1958; 21: 1-16
2 Brunnemann KD, Yu L, Hoffmann D. Assesment of carcinogenic volatile N-nıtrosamınes in tobacco and in mainstream and sidestream smoke from cigarettes. Cancer Res 1977:37: 3218-22.
3 Sugimura T, Sato S, Wakabayashi T. Mutagens: Carcinogens in pyrolsates of amino acids, proteins and cooked food; heterocyclic aromatic amines In: Woo YT, Lai DY, Arcos JT, Ardus MF Chemical induction of cancer. Academic Press, New York 1988:681-710.
4 Hoffman D. Schmeltz 1, Hecht SS, Wynder EL Tobacco carcinogenesis. InGelboin HV, Tso POP, eds Hydrocarbons and Cancer. Vol 1, New York, Academic Press 1978; 85-117.
5 Hoffman D, Adams JD, Lisk D. Fisenne 1, Brunnemann KD. Toxic and carcinogenic agents in dry and moist snuff. J Natl Cancer Inst 1987; 79:1281-6.
6 Hecht SS, Hoffman D The relevance of tobacco-specific nitrosamines to human cancer. Cancer Surv 1989. 8: 273-94.
7 Winn, DM, Blot, WJ, Fraumeni, JF, Jr Snuff dipping and oral cancer. New Engl J Med 1981; 305: 230-1.
8 1ARC Monographs on the evaluation of the Carcinogenic risk of chemicals to humans. Vol. 37, Tobacco habits other than smoking; Betel-quid and Areca-nut chewing; and some related nitrosamines, Lyon 1ARC 1985.
9 Bethesda, MD. US Department of Health and Human Services The health consequences of using smokeless tobacco. NIH 1986 ; 86-2874.
10 Adams JD, O Mara-Adams KJ, Hoffman D. Toxic and carcinogenic agents in undiluted mainstream smoke and sidestream smoke of different types of cigarettes Carcinogenesis 1987; 8: 729-31.
11.1 ARC Monographs on the evaluation of the carcinogenic risk of chemicals to Humans, Tobacco smoking, Lyon. I ARC 1986;38.
12. Joly OG, Lubin JH, Carabajloso M Dark tobacco and lung cancer in Cuba. J Natl Cancer Inst 1983; 70: 1033-9.
13 Deutsch-Wenzel RP, Brune H, Grimmer G, Dettbarn G, Misfeld J. Experimental studies in rat lungs on the carcinogenicity and dose-response relationships of eight frequently occurring environmental polycyclic aromatic hydrocarbons J Natl Cancer Inst 1983;71:539-44
14. Sellakumar. A, & Shubik, P. Carcinogenicity of different polycyclic hydrocarbons in the respiratory tract of hamsters. J Natl Cancer Inst 1974; 53: 1713-6.
15 Stinson. S.F., & Saffiotti, V Experimental respiratory carcinogenesis with polycyclic aromatic hydrocarbons. In: Renzik-Svchuller HM, ed. Comparative respiratory Tract carcinogenesis. Boca Raton.FL, CRC Press, 1983:75-93
16. Saffiotti V, Montesano R, Sellakumar AR, Cefis F. Kaufman DG Respiratory tract carcinogenesis in hamsters induced by different numbers of administrations of benzo [a] pyrene and ferric oxide. Cancer Res 1972;32:1073-81.
17. Harris CC, Autrup H, Connor R, Barrett LA McDowell EM, Trump BF Interindividual variations in binding of benzo [a] pyrene to DNA in cultured human bronchi. Science 1972; 194: 1067-9.
18. Philips DH, Hewer A, Martin CN, Garner RC, King MM Correlation of DNA adduct levels in human lung with cigarette smoking Nature 1988:336: 790-2.
19 Randerath E, Miller RH, Mittal D, Avitts T A, Dunsford HA, Randerath K. Covalent DNA damage in tissues of cigarette smokers as determined by 32P-postlabelling assay J Natl Cancer Inst 1989; 81: 341-7.
20. You M, Candrian U, Maronpot RR, Stoner GD. Anderson MW. Activation of the K-ras protooncogene in spontaneously occurring and chemically induced lung tumours of the strain A mouse. Proc Natl Acad Sci USA 1989; 86: 3070¬4.
21. Belinsky S A, Devereux TR, Stoner GD, Anderson MW. Activation of K-ras protooncogene in lung tumours from mice treated with 4-(N—methyl-N-nitroso)-l-(3-pyridyl)-l-butanone (NNK) or nitrosodimethylamine (NDMA). Proc Am Assoc Cancer Res 1988;29: 139.
22. Little JB, Kennedy AR, McGardy RB. Lung cancer induced by hamsters by low doses of alpha radiation from polonium-210. Science 1975,188: 737-738.
23. Hoffmann A, Hecht SS. Nicotine-derivated N'-
Journal of Turgut Özal Medical Center 1(4): 1994
344
Öztaş H.
Sigarada bulunan bazı kimyasal maddeler ve bunların değişik organlardaki kanserojen etkileri
nitrosamines
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d tobacco related cancer: current status and future directions. Cancer Res 1985; 45:935-44.
24. Hecht SS, Reiss B, Lin D, Williams GM. Metabolism of N'-nitrosonornicotine by cultured rat esophagus. Carcinogenesis 1982:3:453-6.
25. Riverson A, Hoffmann D, Prokopczyk B, Amin S, Hecht SS. Induction of lung and exocrine ancreas tumors in F344 rats by tobacco-specific and areca-derived N-nitrosamines. Cancer Res. 1988;48: 6912-7.

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