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Kronik Lösemilerde Eritrosit İçi Süperoksit Dismutaz Aktiviteleri

Erythrocyte superoxide dismutase activities in chronic leukemias

Journal Name:

  • İnönü Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 1997

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Superoxide dismutase (SOD) enzyme activities were measured in erythrocytes of untreated patients with chronic leukemia by using Podczasy-Wei's INT reduction method. In both types of chronic leukemia, SOD activities were higher than control with respect to averages but there was a meaningful elevation only in CLL type (p<0.05). For these reasons, it can be thought that the gene expressions belonging to SOD were increased in leukemic bone marrow pluripotent stem cells as a part of defense mechanism against to peroxidative damage. [Journal of Turgut Özal Medical Center 1997;4(1):33-
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Abstract (Original Language): 
Kronik lösemili hastalarda henüz tedaviye başlanmadan, eritrosit içi süperoksit dismutaz (SOD) enzim aktiviteleri Podczasy- Wei 'nin tanımladığı INT redaksiyon metodu kullanılarak ölçüldü. KLL ve KML olarak her iki tip lösemide de SOD aktiviteleri ortalamalar yönünden kontrolden daha yüksek olmasına rağmen, sadece KLL grubunda anlamlı yükseklik vardı (p<0.05). Bu bulgulara göre kronik lösemilerde pluripotent stem cell dediğimiz kemik iliği ana hücrelerinde, SOD 'a ait gen ekspresyonunun peroksidatif hasara karşı savunma mekanizmasının bir parçası olarak artırıldığı düşünülebilir. [Turgut Özal Tıp Merkezi Dergisi 1997;4(1):33-36]
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  • 1
33-36
  • Turkish

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