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A COMPARATIVE STUDY OF ARTERIAL STIFFNESS INDICES BETWEEN SMOKERS & NON SMOKERS

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DOI: 
10.5958/j.2319-5886.2.3.094
Abstract (2. Language): 
Arterial stiffening is recognized as a critical precursor of cardiovascular disease. Smoking is one of the modifiable risk factor for cardiovascular disease. Lifestyle modification is clinical efficacious therapeutic interventions for preventing and treating arterial stiffening. Hence, the current study is designed to compare the Arterial Stiffness Indices between smokers & non smokers. The study involved 55 non smokers & 55 smokers within the age group of 30-50 years. Peripheral Pulse Wave was recorded by Digital Volume Pulse in both non smokers & smokers. Arterial stiffness indices were calculated. Arterial Stiffness Index = Patients Height / Transit time [Transit time → Time delay between systolic peak & Diastolic peak] Reflection Index = Magnitude of Diastolic peak / Magnitude of Systolic Peak. Arterial Stiffness Index & Reflection Index were highly significant in smokers than nonsmokers, p<0.001. The increased arterial stiffness indices in smokers suggest that the cigarette smoke damages the vascular endothelium.
FULL TEXT (PDF): 
533-539

REFERENCES

References: 

1. Yambe T, Meng X, Hou X, Wang Q, Sekine
K, Shiraishi Y, Watanabe M, Yamaguchi T,
Shibata M, Kuwayama T, Murayam M,
Konno S, Nitta S. Cardio-ankle vascular
index (CAVI) for the monitoring of the
538
Prabha et al., Int J Med Res Health Sci. 2013;2(3):533-539
atherosclerosis after heart transplantation.
Biomed Pharmacother. 2005;59( 1)177–79.
2. Kiyohara Y, Ueda K, Fujishima M. Smoking
and Cardiovascular-Disease in the General-
Population in Japan. J Hypertens. 1990;8:9–
15.
3. Teo KK, Ounpuu S, Hawken S, Pandey MR,
Valentin V, Hunt D, Diaz R, Rashed W,
Freeman R, Jiang L, Zhang X, Yusuf S, on
behalf of the Interheart Study Investigators.
Tobacco use and risk of myocardial
infarction in 52 countries in the Interheart
study: a case-control study. Lancet. 2006;
368: 647–58.
4. Mahmud A, Feely J. Effect of smoking on
arterial stiffness and pulse pressure
amplification. Hypertension. 2003; 41: 183–
87.
5. S. Binder, K. Navratil, J. Halek. Chronic
smoking and its effect on arterial stiffness.
Biomed Pap Med Fac Univ Palacky Olomouc
Czech Repub. 2008, 152(2):299–02.
6. O'Rourke MF, Pauca A, Juany X-J. Pulse
wave analysis. British Journal of Clinical
Pharmacology, 2001; 6:507-522.
7. Kool MJ, Hoeks AP, Struijker Boudier HA,
Reneman RS, van Bortel LM. Short- and
long-term effects of smoking on arterial wall
properties in habitual smokers. J Am Coll
Cardiol 1993;22:1881-6.
8. Mahmud A, Feely J. Effect of smoking on
arterial stiffness and pulse pressure
amplification. Hypertension 2003;41:183-7.
9. Vlachopoulos C, Alexopoulos N,
Panagiotakos D, O’Rourke MF, Stefanadis C.
Cigar Smoking has an acute detrimental
effect on arterial stiffness. Am J Hypertens
2004;17:299-303.
10. Jatoi NA, Jerrard-Dunne P, Feely J, Mahmud
A. Impact of smoking and smoking cessation
on arterial stiffness and aortic wave reflection
in hypertension. Hypertension 2007;49:981-
5.
11. Failla M, Grappiolo A, Carugo S, Calchera I,
Giannattasio C, Mancia G. Effects of
cigarette smoking on carotid and radial artery
distensibility. J Hypertens 1997;15:1659-64.
12. Janet T Powell. Vascular damage from
smoking: disease mechanisms at the arterial
wall. Vasc Med 1998 3: 21
13. Critchley JA, Capewell S. Mortality risk
reduction associated with smoking cessation
in patients with coronary heart disease.
JAMA. 2003; 290: 86–97.
14. Auerbach D, Hammond EC, Garfi nkel L.
Thickening of walls of arterioles and small
arteries in relation to age and smoking habits.
The New England Journal of Medicine, 1968;
278:908-984.
15. McVeigh GE, LeMay L, Morgan DJ, Cohn
JN. The effect of chronic cigarette smoking
on endothelium-dependent responses in
humans. The American Journal of
Cardiology, 1996; 78:668-672.
16. Zhang JY, Cao YX, Xu CB, Edvinsson L.
Lipid-soluble smoke particles damage
endothelial cells and reduce endotheliumdependent
dilatation in rat and man. BMC
Cardiovasc Disord. 2006; 6: 1–9.
17. Celermajer DS, Sorensen KE,
Georgakopoulos D, Bull C, Thomas O,
Robinson J, Deanfield JE. Cigarette smoking
is associated with dose-related and
potentially reversible impairment of
endothelium-dependent dilation in healthy
young adults. Circulation. 1993; 88: 2149–
2155.
18. Mahmud A, Feely J. Arterial stiffness is
related to systemic inflammation in essential
hypertension. Hypertension. 2005; 46: 1118–
1122.
19. Bakhru A, Erlinger TP. Smoking cessation
and cardiovascular disease risk factors:
results form the Third National Health and
Nutrition Examination Survey. PLoS Med.
2005; 2: e160.
20. Willett, W., Hennekens, C.H., Castelli, W.,
Rosner, B., Evans, D., Taylor, J., Kass, E.H.
Effects of cigarette smoking on fasting
triglyceride, total cholesterol, and HDL539
Prabha et al., Int J Med Res Health Sci. 2013;2(3):533-539
cholesterol in women. American Heart
Journal 1983; 105(3):417-21.
21. Rabkin, S.W. Effect of cigarette smoking
cessation on risk factors for coronary
atherosclerosis: a control clinical trial.
Atherosclerosis.1984;53(2): 173-84
22. Krupski WC, Olive GC, Weber CA, Rapp
JH. Comparative effects of hypertension and
nicotine on injury-induced myointimal
thickening. Surgery.1987;102: 409-15
23. Pittilo RM, Clarke JM, Hams D, Mackie IJ,
Rowles PM, Machin SJ, Woolf N. Cigarette
smoking and platelet adhesion. British
Journal of Haematology. 1984; 58(4): 627-32
24. Selley ML, Bartlett MR, McGuiness JA,
Ardlie NG. Effects of acrolein on human
platelet aggregation. Chemico-
BiologicalInteractions.1990;76(1):101-09
25. Stern S, Bayes de Luna A. Coronary artery
spasm: a 2009 update. Circulation. 2009 May
12;119(18):2531-4.
26. Reddy MV, Randerath K. A comparison of
DNA adduct formation in white blood cells
and internal organs of mice exposed to
benzo[a]pyrene, dibenzo[c,g]carba-zole,
safrole and cigarette smoke
condensate. Mutation
Research. 1990;241(1):37–48
27. Millasseau S. C., Kelly R. P., Ritter J.M., and
Chowenczyk.P.J. Determination of age
related increases in large artery stiffness by
digital pulse contour analysis.J Clinical
Science 2002;103:371-377.
28. Van Schooten FJ, Hirvonen A, Maas LM, De
Mol BA, Kleinjans JCS, Bell DA, Durrer JD.
Putative susceptibility markers of coronary
artery disease: association
between VDR genotype, smoking, and
aromatic DNA adduct levels in human right
atrial tissue. FASEB
Journal. 1998;12(13):1409–17
29. Woodman RJ, Watts GF, Kingwell BA, Dart
AM. Interpretation of the digital volume
pulse: its relationship with large and small
artery compliance. Clinical Science, 2003;
3:283-285

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