FORMULATION AND EVALUATION O F ETHYL CELLULOSE MICROSPHERE OF GLIPIZIDE

In the present study an attempt was made to develop a new sustained drug ^ delivery for Glipizide microspheres by using polymer Ethyl cellulose to improve patient compliance and safety. It is possible to prepare microspheres containing Glipizide by solvent evaporation method, to prolong activity with increased stability without losing its therapeutic activity. Use of this approach has the potential not only to improve the therapeutic effectiveness of the drug but also to allow a reduction in the total drug needed and minimizing toxic side effects. Microspheres are one of the devices that have been used for the delivery of drugs to affected area. Microspheres are relatively non-toxic and non-immunogenic preparations made to reduce the gap between the sustained release preparations and controlled release preparations.