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MODIFIED RELEASE OF DILTIAZEM HYDROCHLORIDE USING TRANSDERMAL DRUG DELIVERY SYSTEM

Journal Name:

  • The International Journal of Pharmaceutical Research and Bio-Science

Publication Year:

  • 2012

Key Words:

Author Name
Abstract (2. Language): 
The objective of present study was to investigate the suitable polymeric films for the development of diltiazem hydrochloride (diltiazem HCl) transdermal drug delivery systems. Hydroxypropyl methylcellulose (HPMC) and ethyl cellulose (EC) were used as hydrophilic and hydrophobic film formers, respectively. Effects of HPMC/EC ratios and plasticizers on mechanical properties of free films were studied. Matrix films were evaluated for their physicochemical characterization followed by in vitro evaluation. The Thickness and weight of patch increase with the increase in polymeric grade and content. Fourier transforms infrared spectroscopy results confirmed that there is no interaction between drug and polymer used. The in vitro drug release followed Higuchi kinetic as its coefficient of correlation values predominates over first order kinetics. Comparison of skin permeation rate between hairless rat and human cadaver skin was done by using diffusion cells. Out of the various formulations made, the selected formulations are better in their in vitro dissolution thus holds potential for transdermal delivery.
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