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FORMULATION AND EVALUATION OF FLOATING TABLET OF CEFUROXIME AXETIL

Journal Name:

  • The International Journal of Pharmaceutical Research and Bio-Science

Publication Year:

  • 2012

Key Words:

Author Name
Abstract (2. Language): 
The aim of the present work was to design and development of hydro dynamically balanced tablet of Cefuroxime Axetil to enhance the bioavailability and therapeutic efficacy of the drug. Cefuroxime Axetil is classified as a second-generation cephalosporin antibiotic and beta lactum antibiotics based on spectrum activity. Tablets are prepared by the wet granulation technique by using Eudragit RL 100, Hydroxypropyl methyl cellulose and their combination as polymers along with sodium bicarbonate as gas generating agent. Formulations were evaluated for in vitro buoyancy and drug release stu using up dissolution apparatus using 0.1N HC The result indicate that floating tablets of Cefuroxime Axetil containing combination of HPMC K4M: 100 provides a better option for control release action and improved bioavailability than Plain polymers containing formulations such as Eudragit RL. respectively.
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  • 5
184-192
  • English

REFERENCES

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