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A COMPARATIVE STUDY ON HEPATOPROTECTIVE ACTIVITY OF BOERHAAVIA DIFFUSA AND SILYMARIN IN CCI4 INDUCED HEPATOTOXICITY IN ALBINO RABBITS

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Abstract (2. Language): 
Objective:To compare the hepatoprotective activity of Silymarin in CCl4 induced hepatotoxicity in albino Rabbits. Methods: The study was conducted on 18 healthy albino rabbits of either sex weighing 1.5-2.0 kg , divided into 3 groups. Hepatotoxicity was induced in rabbits by carbon tetra chloride (CCl4) 0.05 mg /kg ,intraperitonealy. extracts of roots of Boerhaavia diffusa and Silymarin for 20 days from 1 day to day 20 in the doses of 100mg/kg/day with the help of syringe. Results: Group I: The rise of serum transaminase(p<0.001 )., serum alkaline phosphatase(p<0.001 )., serum bilirubin (p<0.001 ) and decrease in serum albumin (p<0.001 )due to hepatotoxic effect of CCl zero day of same group (p<0.001 ). Group II: B fall in the level of serum transaminase , serum alkaline phosphatase ,serum bilirubin and increased in serum albumin in a statistical highly significant amount (p<0.001), when compared with 11 (group I). Group III: Silymarin was decrease the level of SGOT (p<0.0001), serum alkaline phosphatase (p< 0.0001), (p<0.0001)and increased in serum albumin (p<0.0001) in a statistical highly significant amount , when compared with11 significance difference (p>0.10) found in SGOT, SGPT Albumin respectively when we compared group II & group III ISSN: 2277-8713 IJPRBS College, Agra. Medical College, , Kanpur. :Boerhaavia diffusa and Materials and : ) Alcoholic were administered orally : CCl4 when compared to : Boerhaavia diffusa extract caused th day of rabbits receiving CCl4 : (p<0.0001), SGPT serum bilirubin th day of Group I . There is no gnificance SGPT, ALP, S. bilirubin, S. e III.
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Group Mean Serum
Albumin (gm/dl) ±
SE At zero day
Mean Serum
Albumin (gm/dl) ±
SE At 11th day
Mean Serum Albumin
(gm/dl) ±SE At 21th day
I
(CCl4)
4.00±0.10 2.33±0.07* -$
II
(Boerhaavia
diffusa extract)
4.12±0.18 4.13±0.18**,& 3.13±0.12***,##,&
III
(Silymarin)
4.17±0.10 4.20±0.07**,& 4.17±0.09**,#,&
Research Article ISSN: 2277-8713
Jain Anurag, IJPRBS, 2013; Volume 2(1): 78-95 IJPRBS
Available Online At www.ijprbs.com
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