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PREPARATION AND EVALUATION OF IN-SITU GEL OF LEVOFLOXACIN HEMIHYDRATE FOR TREATMENT OF PERIODONTAL DISEASE

Journal Name:

  • The International Journal of Pharmaceutical Research and Bio-Science

Publication Year:

  • 2013

Key Words:

Author Name
Abstract (2. Language): 
The aim of this study is to report the development, formulation and evaluation of thermo responsive in-situ gelling drug delivery system of Levofloxacin hemihydarte and its inference for the treatment of periodontal disease. A local controlled release system for direct placement of drug into the periodontal pocket without incision is developed using various concentrations of Polaxomer 407, which exhibits sol-to-gel phase transition converting to gel at body temperature (370 C) from liquid at room temperature (250 C). This type of drug delivery systems are considered as adjunctive to mechanical debridement viz. scaling and root planning benefiting more drugs at the target site. Each Formulation was evaluated for parameters like physicochemical properties, viscosity, gelation pH, gelation temperature, spreadability, in-vitro release, stability testing. Experimental part showed that viscosity of sols and gel strength was increased with increase in the concentration of polymers and the sustained release of drug was observed. The system thus developed was found to be clear and have good viscosity with prolonged release at 37°C, pH and drug content of all formulations was found to be satisfactory.
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  • 3
185-196
  • English

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