You are here

Home » Content

BİR OTOİMMÜN KOLANJİT VAKASI

Journal Name:

  • İstanbul Tıp Fakültesi Dergisi

Publication Year:

  • 2002

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
An autoimmıme cholangitis case. Autoimmune cholangitis is a chronic inflammatory liver di-sease characterized by cholestatic and hepatocellular findings. Most of affected patients are middle age women and present with itching, fatigue, arthralgia and jaundice. The disease re-sembles primary biliary cirrhosis histologically, however distinction betvveen the diseases is made by positive antinuclear antibody and/or antismooth muscle antibody, and negative anti-mitochondrial antibody titers. Eliminating other causes of liver damage confirms the diagno-sis. Management includes use of immunosuppresive agents and uısodeoxycholic acid. Its prognosis is poorer than that of biliary cirrhosis. Because it is a newly defined and rare disease, we present a case that was admitted to, and whose diagnosis was confirmed in our clinic
Bookmark/Search this post with
Abstract (Original Language): 
Otoimmun kolanjit kolestatik ve hepatoselüler özelliklere sahip kronik inflamatuar bir karaciğer hastalığıdır. Hastalar çoğunlukla orta yaşlı kadınlardır ve kaşıntı, yorgunluk, artralji, sarılık yakınması ile başvururlar. Histolojik olarak primer biliyer siroz ile benzerlik gösteren bu hastalık, esasen antinükleer antikor ve/veya antidüz kas antikor pozitifliği, antimitokondriyal antikor negatifliği ile ondan ayrılan bir antitedir. Karaciğer hasarına ait diğer etiyolojik nedenlerin dışlanması ile tanı kesinleştirilir. Tedavide immunsüpressif ajanlar ve ursodeoksikolik asid kullanılmaktadır. Prognozu primer biliyer siroza göre daha kötüdür. Yeni tanımlanan ve nadir görülen bir hastalık olması nedeni ile kliniğimizde yatırılarak tanısı kesinleştirilen bir olgu burada sunulmuştur
FULL TEXT (PDF): 
PDF icon arastirmax-bir-otoimmun-kolanjit-vakasi.pdf
  • 1
53-56
  • Turkish

REFERENCES

References: 

1. Albert J. Czaja, Herschel A Carpenter, Paula j. Santrach. et al: Autoimmune cholangitis vvithin the spectrıım of autoimmune liver disease. Hepatology 31:1231 (2000).
2. John M. Vierling: Clinics in liver disease, Autoimmun cholangiopathy, North America Series, Los Angeles, (1999), Sf.:571.
3. Kawaguchi N, Miyakawa H, Abe K. et al: Western blot analysis of anti-M2 antibodies in anti-mitochondrial anti-body-negative primary biliary cirrhosis. Rinsho Byori 11:1079(1997).
4. Kinoshita H, Omagari K, Whittingham S. et al: Autoimmune cholangitis and primary biliary cirrhosis an autoimmune enigma. Liver 2:122 (1999).
5. Masumoto T, Ninomiya T, Michitaka K. et al: Three pati-ents with autoimmune cholangiopathy treated with predni-solone. J Gastroenterol 6:909 (1998).
6. Sherlock DS. Autoimmune cholangitis: a unique entity? Mayo Clin Proc 73:184 (1998).

Thank you for copying data from http://www.arastirmax.com