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BAZI KANAL PATLARININ SİTOTOKSİSİTELERİNİN İNCELENMESİ

INVESTIGATION OF CYTOTOXICITY OF SOME ROOT CANAL SEALERS

Journal Name:

  • İstanbul Üniversitesi Diş Hekimliği Fakültesi Dergisi

Publication Year:

  • 1994

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Cytotoxicity of various root canal sealers (Sealapex, Grossman, Ketac-Endo, Diaket, CRCS veAH26) in KB cell line (human epidermoid carcinoma) was investigated by sulforhodamine B test. Root canal sealers were prepared according to the instructions of the manufacturer and tested at final concentrations of25, 250 ve 2500p%lml with respect to powder or creme part. All the root canal sealers other than Diaket inhibited the growth of KB cells in a do-se-depent manner. At 2500\igjml, AH 26, Grosman, CRCS, Sealapex, Diaket ve Ketac Endo inhibited the growth by 100%, 95%, 94%, 83%, 73% and 23%, respectively. Conclusively, Ketac Endo was found to be the least toxic root canal sealer, whereas CRCS, AH26 and Grossman seem the most toxic sealers at 2500fig/ml. On the other hand, Diaket and Grossman were the most cytotoxic sealers at 25\igjml.
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Abstract (Original Language): 
Bu çalışmamızda değişik kanal patlarının (Sealapex, Grossman, Ketac-Endo, Diaket, CRCS ve AH26) KB hücreleri (epidermoid karsİnom, insan) üzerindeki sitotoksik etkileri SRB testi ile incelenmiştir. Kanal patlan İmalatçının tarifine uygun olarak hazırlanmış ve toz veya krem kısım esas alındığında 25, 250 ve 2500u,g/ml nihai konsantrasyonunda denenmiştir. Diaket haricindeki tüm patların etkisi doz düşürülünce azalmıştır. 2500 ng/ml konsantrasyonunda AH 26 %100, Grossman %95, CRCS %94, Sealapex %83, Diaket %73, ve Ketac Endo %23 oranında toksi-sİte göstermiştir. Sonuç olarak, 2500^g/ml konsantrasyonunda en az toksik patın Ketac-Endo ve en fazla toksik patların AH26, CRCS ve Grossman olduğu görülmektedir. Diğer yandan, konsantrasyon 25\ıg/mVa düşürüldüğü zaman Diaket ve Grossman en fazla sitotoksik bulunmuştur.
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  • Turkish

REFERENCES

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