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FARKLI HIZLARDA DİSTRAKTE EDİLEN SIÇAN GASTROKNEMİUS KASINDA MEYDANA GELEN DEĞİŞİKLİKLERİN ELEKTRON MİKROSKOBU İLE İNCELENMESİ

EVOLUATION OF THE CHANGES IN GASTROCNEMIUS MUSCLE OF RATS DISTRACTED IN DIFFERING PACES WITH ELECTRON MICROSCOPE

Journal Name:

  • İstanbul Üniversitesi Diş Hekimliği Fakültesi Dergisi

Publication Year:

  • 2011

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Lengthening of the rodent tibia using an external device was performed to study gastrocnemius muscle subjected to stretch in different paces. Three male Sprouge Dawley rats were used as one for control group, others for 0.50 mm, 0.75 mm distraction per a day. The distractors were placed in right tibial bones. After the replacement of distractors one rat was set for 0.50 mm distraction through one week and the other one for 0.75 mm distraction under the same conditions. At the end of one week, rats were sacrificed. The control rat was sacrificed without being distracted after five days of replacing the distractor. We ended up with differing glycogen levels, mitochondrion gatherings and dilations of T tubules in the muscle tissue specimens of distracted rats in different velocities. Further studies are needed for statistical analysis and clinical applications.
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Abstract (Original Language): 
Fizyolojik sınırlar içinde, farklı hızlarda gerilim uygulanan sıçan gastroknemius kasında meydana gelen değişikliklerin elektron mikroskobu ile incelenmesidir. Çalışmamızda kontrol, 0.50 mm/gün, 0.75 mm/gün olarak distrakte edilen üç adet yetişkin Sprouge Dawley cinsi sıçan kullanılmıştır. Distraktörler, sıçanların sağ tibialarına yerleştirildikten iki gün sonra biri 0.50 mm/gün, diğeri 0.75 mm/gün olmak üzere aym koşullar altında bir hafta boyunca distrakte edilmiş ve hayvanlar birinci haftanın sonunda sakrifıye edilmiştir. Kontrol grubundaki sıçan ise distrakte edilmeden 5. günün sonunda sakrifıye edilmiş alınan kas örnekleri elektron mikroskobunda incelenmiştir. Farklı hızlarda distrakte edilen kas örnekleri karşılaştırıldığında görülen değişiklikler; glikojen yoğunluğu, mitokondri kümeleşmeleri, T tübüllerindeki dilatasyon miktan ve mitokondriumlarda endoülazmik retikulumda damar endotelinde değişiklikler seklinde özetlenebilir Bu üilot çalışmada elde ettiğimiz verilerin istatistiksel değerlendirmesinin yapılabilmesi v Sonuçların kliniğe uygulanması ıçm ilen çalışmalara gereksinim vardır.
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