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PROBİYOTİKLER VE AĞIZ SAĞLIĞINA ETKİLERİ

PROBIOTICS AND EFFECTS ON ORAL HEALTH

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Abstract (2. Language): 
This article summarizes the currently available data on the potential benefits of probiotics for oral health. Bacteria known as probiotics have been added to various foods because of their beneficial effects for human health. Recent experimental studies and results from randomized controlled trials have shown that certain gut bacteria, in particular species of Lactobacillus and Bifid bacterium, may exert beneficial effects in the oral cavity by inhibiting cariogenic Streptococci and Candida sp. Probiotics have been successfully used to control gastro¬intestinal diseases. They also appear to alleviate symptoms of allergy and diseases with immunological pathology. The mechanism of action of probiotics is link with their ability to compete with pathogenic microorganisms for adhesion sites, to antagonize these pathogens or to modulate the host's immune system. Probiotic bacteria can produce different antimicrobial components such as organic acids, hydrogen peroxide, carbon peroxide, diacetyl, bacteriosins, which also affect oral micro flora. However, data is still insufficient on the probiotic action in the oral cavity. More information is needed on the colonization of probiotics in the mouth and their possible effect on and within oral bio-films.
Abstract (Original Language): 
Bu derleme, ağız sağlığı üzerine probiyotiklerin potansiyel etkileriyle ilgili mevcut bilgilerin özetlenmesini hedeflemektedir. İnsan sağlığı için yararlı etkilerinden dolayı çeşitli besinlere eklenen bakteriler, probiyotik olarak bilinmektedir. Son zamanlarda yapılan deneysel ve rastgele kontrollü deneysel çalışmaların sonuçlarına göre, özellikle Lactobacillus ve Bifidobacterium gibi bağırsak bakterilerinin, ağız boşluğundaki karyojenik Streptococcus ve Candida türlerinin üremesini önleyerek olumlu etkiler sağlamak amacıyla kullanılabileceği düşünülmektedir. Probiyotikler, bağırsak hastalıklarında başarıyla kullanılmıştır. Bu bakterilerin immün sistem hastalıklarını ve alerjik hastalık belirtilerini azalttığı düşünülmektedir. Etki mekanizmalarının, patojenik mikroorganizmaların yapışma alanlarında onlara karşı rakip olmaları, bu patojenleri engellemeleri ve konağın bağışıklık sistemini modifiye edebilmeleriyle ilişkili olduğu sanılmaktadır. Probiyotik bakteriler aynı zamanda ağız florasını etkileyen organik asitler, hidrojen peroksit, karbon peroksit, diasetil, bakteriosin gibi farklı antimikrobiyal maddeleri de üretebilir. Fakat bu bakterilerin ağız boşluğundaki aktiviteleri üzerine bilgiler yetersizdir. Ağızdaki probiyotik kolonizasyonu ve ağız mikroflorası üzerine olan etkileri üzerine daha çok çalışma yapılmasına ihtiyaç vardır.
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REFERENCES

References: 

1. Beers MH, Berkow R. Infectious diseases: antibacterial drugs. In: The Merck Manual, 17th edn. Whitehouse Station: Merck Research Laboratories, p:1101-1127, 1999.
2. Ashwell M. Concepts of functional foods. Brussels: ILSI Europe, 2002.
3. Parvez S, Malik KA, Ah Kang S, Kim HY. Probiotics and their fermented food products are beneficial for health. J Appl Microbiol 2006; 100: 1171-1185.
4. De Vrese M, Schrezenmeir J. Probiotics, prebiotics, and synbiotics. Adv Biochem Eng
Biotechnol 2008; 111: 1-66.
5. Gueimonde M, Salminen S. New methods for selecting and evaluating probiotics. Dig Liver Dis 2006; 38:242-247.
6. Guidelines for the evaluation of probiotics in food. Joint FAO/WHO Working Group Report on Drafting Guidelines for the Evaluation of Probiotics in
Food. 2002. Available:
ftp://ftp.fao.org/es/esn/food/wgreport2.pdf.
7. Salminen S, Boyley C, Boutron-Ruault M-C, Cummings JH. Functional food science and
Çetin, Karabekiroğlu ve Ünlü gastrointestinal physiology and function. Br J Nutr
1998; 80: 147-171.
8. Fuller R. Probiotics in human medicine. Gut 1991; 32: 439- 442.
9.
Le
e Y-K, Salminen S. The coming of age of probiotics. Trends Food Sci Technol 1995; 6: 241¬245.
10. Gorbach SL. Probiotics and gastrointestinal
health. Am J Gastroenterol 2000; 95: 2-4.
11. Tuomola E, Crittenden R, Playne M, Isolauri E, Salminen S. Quality assurance criteria for probiotic bacteria. Am J Clin Nutr 2001; 73: 393-398.
12. Roberfroid MB. Prebiotics and probiotics: are they functional foods? Am J Clin Nutr 2000; 71:
1682-1687.
13. Van Loo J, Jonkers N. Evaluation in human volunteers of the potential anticarcinogenic activities of novel nutritional concepts: prebiotics, probiotics and synbiotics. Nutr Metab Cardiovasc Dis 2001; 11:
87-93.
14. Gorbach SL. The discovery of Lactobacillus GG. Nutr Today 1996; 31: 2-4.
15. Saxelin M. Lactobacillus GG - a human probiotic strain with thorough clinical documentation. Food Rev Int 1997; 13: 293- 313.
16. Silva M, Jacobus NV, Deneke C, Gorbach SL. Antimicrobial substance from a human Lactobacillus strain. Antimicrob Agents Chemother 1987; 31:
1231-1233.
17. Gibson GR, Roberfroid MB. Dietary
modulation of the human colonic microbiota: introducing the concept of prebiotics. J Nutr 1995; 125:1401-1412.
18. Andersson H, Asp NG, Bruce A, Roos S, Wadstrom T, Wold AE. Health effects of probiotics and prebiotics: a literature review on human studies.
Scand J Nutr 2001; 45: 58-75.
Probiyotikler ve
Ağı
z Sağlığına Etkileri
26
©Süleyman Demirel Üniv Diş Hek Fak Derg Cilt/Vol.:3 Sayı/No.:1 Sayfa/Page:19-29, 2011
19. Ouwehand AC. Antimicrobial components from LAB. In: Salminen S, Wright A, eds. Lactic acid bacteria. New York: Marcel Dekker Inc. p: 139-159,
1998.
20. Kang MS, Na HS, Oh LS. Coaggregation
ability of Weissella cibaria isolates with Fusobacterium nucleatum and their adhesiveness to
epithelial cells. FEMS Microbiol Lett 2005; 253: 323¬329.
21.
Osteng
o MC, Nader-Macias EM. Hydroxylapatite beads as an experimental model to study adhesion of lactic acid bacteria from the oral
cavity to hard tissues. Methods Mol Biol 2004; 268: 447-452.
22. Kolenbrander PE. Oral microbial communities: biofilms, interactions, and genetic
systems. Annu Rev Microbiol 2000; 54: 413-437.
23. Reid G, McGroarty JA, Angotti R, Cook RL.
Lactobacillus inhibitor production against Escherichia coli and coaggregation ability with uropathogens. Can J Microbiol 1988; 34: 344-351.
24. Boris S, Suarez JE, Barbes C. Characterization of the aggregation promoting factor from Lacobacillus gasseri, a vaginal isolate. J Appl
Microbiol 1997; 83: 413-420.
25. Haukioja A, Yli-Knuuttila
H
, Liomaranta V, Kari K, Ouwehand AC, Meurman JH, Tenovuo J. Oral adhesion and survival of probiotic and other lactobacilli and bifidobacteria in vitro. Oral Micorbiol
Immunol 2006; 21: 326-332.
26. Haukioja A, Loimarant V, Tenovuo J. Probiotic bacteria affect the composition of salivary pellicle and streptococcal adhesion in vitro. Oral
Microbiol Immunol 2008; 23: 336-343.
27. Wu H-Y, Nguyen HH, Russell MW. Nasal
lymphoid tissue (NALT) as a mucosal immune inductive site. Scand J Immunol 1997; 46: 506-513.
Çetin, Karabekiroğlu ve Ünlü
28. Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998; 392: 245¬252.
29. Hart AL, Lammers K, Brigidi P, Vitali B,
Rizzello F, Gionchetti P, Campieri M, Kamm MA, Knight SC, Stagg AJ. Modulation of human dendritic cell phenotype and function by probiotic bacteria. Gut
2004; 53: 1602-1609.
30. Mınna R, Kallıomakı M, Arvılommı H, Salmınen S, Isolaurı E. Effect of Probiotics and Breastfeeding on the Bifidobacterium and Lactobacillus/Enterococcus Microbiota and Humoral
Immune Responses. J Pediatr 2005; 147: 186-191
31. Teanpaisan R, Dahlen G. Use of polymerase chain reaction techniques and sodium dodecyl sulfate-polyacrylamide gel electrophoresis for differentiation of oral Lactobacillus species. Oral Microbiol
Immunol 2006; 21: 79-83.
32. Meurman JH, Stamatova I. Probiotics:
contributions to oral health. Oral Dis 2007; 13: 443¬451.
33. Sookkhee S, Chulasiri M, Prachyabrued W. Lactic acid bacteria from healthy oral cavity of Thai volunteers: inhibition of oral pathogens. J Appl
Microbiol 2001; 90: 172-179.
34. Meurman JH, Antila H, Salminen S. Recovery of Lactobacillus strain GG (ATCC 53103) from saliva of healthy volunteers after consumption of yoghurt prepared with the bacterium. Microbiol Ecol Health Dis 1994; 7: 295-298.
35. Yli-Knuuttila H, Snâll J, Kari K, Meurman JH. Colonization of Lactobacillus rhamnosus GG in the oral cavity. Oral Microbiol Immunol 2006; 21:
129-131.
36. Miller WD. Micro-organisms of the human
mouth. Philadelphia: SS White, 1890.
27
Probiyotikler ve
Ağız Sağlığına Etkileri
©Süleyman Demirel Üniv Diş Hek Fak Derg Cilt/Vol.:3 Sayı/No.:1 Sayfa/Page:19-29, 2011
37. Keyes PH. Research in dental caries. J Am Dent Assoc 1968: 76: 1357-1373.
38. Fitzgerald RJ, Fitzgerald DB, Adams BO,
Duany LF. Cariogenicity of human oral lactobacilli in hamsters. J Dent Res 1980: 59: 832-837.
39. Gedalia I, Ionat-Bendat D, Ben-Mosheh S,
Shapira L. Tooth enamel softening with a cola type drink and rehardening with hard cheese or stimulated
saliva in situ. J Oral Rehabil 1991; 18: 501-506.
40. Jensen ME, Wefel JS. Effects of processed cheese on human plaque pH and demineralization and remineralization. Am J Dent 1990; 3: 217-223.
41. Comelli EM, Guggenheim B, Stingele F, Neeser JR. Selection of dairy bacterial strains as probiotics for oral health. Eur J Oral Sci 2002; 110:
218-224.
42. Nâse L, Hatakka K, Savilahti E, Saxelin M,
Pönkâ
A
, Poussa T. Effect of long-term consumption of a probiotic bacterium, Lactobacillus rhamnosus GG, in milk on dental caries and caries risk in children. Caries Res 2001; 35: 412-420.
43. Meurman JH, Antila H, Korhonen A, Salminen S. Effect of Lactobacillus rhamnosus strain GG (ATCC 53103) on the growth of Streptococcus sobrinus in vitro. Eur J Oral Sci 1995; 103: 253-258.
44. Petti S, Tarsitani G, Simonetti D'Arca A. Antibacterial activity of yoghurt against viridans streptococci in vitro. Arch Oral Biol 2008; 53: 985¬990.
45. Ahola AJ, Yli-Knnuuttila H, Suomalainen T, Poussa T, Ahlström A, Meurman JH. Short-term consumption of probiotic-containing cheese and its effect on dental caries risk factors. Arch Oral Biol
2002; 47: 799-804.
46. Caglar E, Kavaloglu SC, Kuscu OO, Sandalli N, Holgerson PL, Twetman S. Effect of chewing gums containing xylitol or probiotic bacteria on
Çetin, Karabekiroğlu
v
e Ünlü salivary mutans streptococci and lactobacilli. Clin Oral Investig 2007; 11: 425-429.
47. Nikawa H, Makihira S, Fukushima H, Nishimura H, Ozaki K, Darmawan S. Lactobacillus reuteri in bovine milk fermented decreases the oral carriage of mutans streptococci. Int J Food Microbiol
2004; 95: 219-223.
48. Caglar E, Cildir SK, Ergeneli S, Sandalli N,
Twetman S. Salivary mutans streptococci and lactobacilli levels after ingestion of the probiotic bacterium Lactobacillus reuteri ATCC 55730 by straws or tablets. Acta Odontol Scand 2006; 64: 314¬318.
49. Hatakka K, Savilahti E, Ponka A, Meurman JH, Poussa T, Nase L, Saxelin M, Korpela R. Effect of long term consumption of probiotic milk on infections in children attending day care centres: double blind, randomised trial. Br Med J 2001; 322:
1327.
50. Caglar E, Sandalli N, Twetman S, Kavaloglu S, Ergeneli S, Selvi S. Effect of yogurt with Bifidobacterium DN-173 010 on salivary mutans streptococci and lactobacilli in young adults. Acta Odontol Scand 2005; 63: 317-320.
51. Montalto M, Vastola M, Marigo L, Covino M, Graziosetto R, Curigliano V, Santoro L, Cuoco L, Manna R, Gasbarrini G. Probiotic treatment increases salivary counts of lactobacilli: a double-blind, randomized, controlled study. Digestion 2004; 69: 53¬56.
52. Houle MA, Grenier D. Maladies parodontales: connaissances actuelles. Current concepts in periodontal diseases. Medecine et maladies infectieuses. 2003; 33: 331-340.
53. Koll-Klais P, Mândar R, Leibur E, Marcotte
H, Hammarström L, Mikelsaar M. Oral lactobacilli in chronic periodontitis and periodontal health: species
Probiyotikler ve
Ağız Sağlığına Etkileri
28
©Süleyman Demirel Üniv Diş Hek Fak Derg Cilt/Vol.:3 Sayı/No.:1 Sayfa/Page:19-29, 2011
Çetin, Karabekiroğlu ve Ünlü
composition and antimicrobial activity. Oral
Microbiol Immunol 2005; 20: 354-361.
54. Krasse P, Carlsson B, Dahl C, Paulsson A, Nilsson A, Sinkiewicz G. Decreased gum bleeding and reduced gingivitis by the probiotic Lactobacillus
reuteri. Swed Dent J 2006; 30: 55-60.
55. Gânzle MG, Holtzel A, Walter J, Jung G,
Hammes WP. Characterization of reutericyclin produced by Lactobacillus reuteri LTH2584. Appl
Environ Microbiol 2000; 66: 4325-4333.
56. Talarico TL, Casas IA, Chung TC, Dobrogosz WJ. Production and isolation of reuterin, a growth inhibitor produced by Lactobacillus reuteri.
Antimicrob Agents Chemother 1988; 32: 1854-1858.
57. Mukai T, Asasaka T, Sato E, Mori K,
Matsumoto M, Ohori H. Inhibition of binding of
Helicobacter
pylori to the glycolipid receptors by probiotic Lactobacillus reuteri. FEMS Immunol Med Microbiol 2002; 32: 105-110.
58. Ma D, Forsythe P, Bienenstock J. Live Lactobacillus reuteri is essential for the inhibitory effect on tumor necrosis factor alpha-induced interleukin-8 expression. Infect Immun 2004; 72:
5308-5314.
59. Pena JA, Rogers AB, Ge Z, Ng V, Li SY, Fox JG, et al. Probiotic Lactobacillus spp. diminish Helicobacter hepaticus-induced inflammatory bowel disease in interleukin-10-deficient mice. Infect Immun
2005; 73: 912-920.
60. Riccia DN, Bizzini F, Perilli MG, Polimeni A,
Trinchieri V, Amicosante G, et al. Anti-inflammatory effects of Lactobacillus brevis (CD2) on periodontal
disease. Oral Dis 2007; 13: 376-385.
61. 61. Narva M, Halleen J, Vâânânen K, Korpela R. Effects of Lactobacillus helveticus fermented milk
on bone cells in vitro. Life Sci 2004; 75: 1727-1734.
62. Scully C, Greenman J. Halitosis (breath odor).
Periodontol 2000. 2008; 48: 66-75.
63. Kang MS, Kim BG, Chung J, Lee HC, Oh JS.
Inhibitory effect of Weissella cibaria isolates on the production of volatile sulphur compounds. J Clin
Periodontol 2006; 33: 226-232.
64. Hyink O, Wescombe PA, Upton M, Ragland N, Burton JP, Tagg JR. Salivaricin A2 and the novel lantibiotic salivaricin B are encoded at adjacent loci on a 190-kilobase transmissible megaplasmid in the oral probiotic strain Streptococcus salivarius K12.
Appl Environ Microbiol. 2007; 73: 1107-1113.
65. Burton JP, Chilcott CN, Moore CJ, Speiser G,
Tagg JR. A preliminary study of the effect of probiotic Streptococcus salivarius K12 on oral malodour parameters. J Appl Microbiol 2006; 100:
754-764.
66. Burton JP, Chilcott CN, Tagg JR. The
rationale and potential for the reduction of oral malodour using Streptococcus salivarius probiotics. Oral Dis 2005; 11: 29-31.

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