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Son Dönem Böbrek Yetmezlikli Hastalarda Malnütrisyon-înflamasyon-Ateroskleroz (MİA Sendromu)

Malnutrition-Inflammation-Atherosclerosis (MIA Syndrome) in ESRD Patients

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 2005

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Malnutrition, inflammation and accelerated atherosclerosis are common in end-stage renal disease (ESRD) patients. All these parameters are the causes of morbidity and mortality in this population. It is known that ESRD patients had a high level of pro-inflammatory cytokine and serum C-reactive protein. MIA syndrome was defined as the interaction between increased pro-inflammatory cytokine and malnutrition and atherosclerosis in ESRD patients by Stenvinkel et al in 2000. As the components of MIA syndrome increase, the morbidity and mortality increase and survival decreases in ESRD patients. For this reason it is supposed that morbidity and mortality would decrease and survival would increase with the treatment of malnutrition, inflammation and atherosclerosis.
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Abstract (Original Language): 
Kronik böbrek yetmezlikli hastalarda malnütrisyon, inflamasyon ve akselere ateroskleroz gelişimine sık rastlanmaktadır. Her üç parametre de son dönem böbrek yetmezlikli (SDBY) hastalarda ayrı ayrı morbidite ve mortalite nedenidir. SDBY hastalarının yüksek proinflamatuar sitokin düzeylerine ve yüksek CRP (C-reaktif protein) düzeyine sahip olduğu bilinmektedir. 2000 yılında Stenvinkel ve arkadaşları tarafından ortaya atılan MİA sendromunun veya hipotezinin temelini; SDBY hastalarında artmış serum proinflamatuar sitokin düzeyleri ile bu hastalarda sıklıkla görülen malnütrisyon ve başlıca morbidite ve mortalite nedeni olan akselere ateroskleroz gelişimi arasındaki ilişki oluşturmaktadır. MİA sendromunun komponentlerinin artmasıyla SDBY hastalarında morbidite ve mortalite artmakta ve yaşam süresi azalmaktadır. Bu nedenle SDBY hastalarında malnütrisyon, inflamasyon ve akselere ateroskleroz gelişimi ile etkin mücadele edilmesinin morbiditeyi ve mortaliteyi azaltacağı ve yaşam süresini uzatacağı düşünülmektedir.
FULL TEXT (PDF): 
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  • 4
160-165
  • Turkish

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