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Lupus Nefropatili Bir Hastada Sistemik Lupus Eritematosusa Bağlı Gastrointestinal Sistem Vaskülopatisi

Systemic Lupus Erythematosus Associated Gastrointestinal System Vasculopathy in a Patient with Lupus Nephropathy

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 2011
DOI: 
10.5262/tndt.2011.1003.15

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Gastrointestinal system (GIS) manifestations are common in systemic lupus erythematosus (SLE) patients. The gastrointestinal vasculopathy of SLE is a unique clinical entity and reviewed infrequently but it should be kept in mind to give the necessary treatment with corticosteroids and other immunosuppressive agents and to avoid non-essential surgical interventions. Here we report a 33-yearold SLE patient that presented with surgical acute abdomen symptoms, was followed-up in a Nephrology Department, and was well managed with high doses of corticosteroids and cyclophosphamide after the diagnosis of GIS vasculopathy.
Abstract (Original Language): 
Sistemik lupus eritematosus (SLE) hastalarında gastrointestinal sistem (GİS) semptomları sıktır. SLE’ ye bağlı GİS vaskülopatisi daha önce literatürde az bildirilmiş nadir bir klinik durumdur fakat kortikosteroidler ve diğer immünosüpresifl erle doğru tedavinin verilmesi ve gereksiz cerrahi uygulamalardan kaçınılması açısından akılda tutulması gerekir. Burada SLE tanısıyla Nefroloji Bölümünde takip edilen ve akut batın semptomlarıyla başvuran 33 yaşındaki hastanın GİS vaskülopati tanısı konulduktan sonra yüksek doz kortikosteroid ve siklofosfamidle tedavisi anlatılmaktadır.
FULL TEXT (PDF): 
PDF icon arastrmx_172977_20_pp_295-298.pdf

REFERENCES

References: 

1. Nguyen H, Khanna N: Intestinal Pseudo-obstruction as a Presenting
Manifestation of Systemic Lupus Erythematosus: Case Report and
Rewiew of the Literature. Southern Medical Association, 2004;
186-189
2. Leclair MA, Plaisance M, Balfour S, Touchette M: Chronic
intestinal pseudo-obstruction in systemic lupus erythematosus.
Canadian Journal of General Internal Medicine 2008; 3(1): 18-20
3. Klippel JH: Systemic lupus erythematosus: Demographics,
prognosis and outcome. J Rheumatol 1997; 48: 67-71
4. Grimbacher B, Huber M, Kempis J, Kalden P, Uhl M, Köhler G,
Blum HE: Successful Treatment of Gastrointestinal Vasculitis
due to systemic lupus erythematosus with intravenous pulse
cyclophosphamide: A clinical case report and review of the
literature. British Society for Rheumatology 1998; 37: 1023-1028
5. Sultan SM, Ioannou Y, Isenberg DA: A review of gastrointestinal
manifestations of systemic lupus erythematosus. Rheumatology
1999; 38: 917-932
6. Hallegua DS, Wallace DJ: Gastrointestinal manifestations of
systemic lupus erythematosus. Curr Opin Rheumatol 2000; 12:
379-385
7. Del Papa N, Guidali L, Sala A, Buccellati C, Khamashta MA,
Ichikawa K, Koike T, Balestrieri G, Tincani A, Hughes GR, Meroni
PL: Endothelial cells as target for antiphospholipid antibodies.
Human polyclonal and monoclonal anti-β2-glycoprotein I
antibodies react in vitro with endothelial cells through adherent β2-
glycoprotein I and induce endothelial activation. Arthritis Rheum
1997; 40: 551-561
8. Cervera R, Espinosa G, Cordero A, Oltra MR, Unzurrunzaga A,
Rossiñol T, Plaza J, Bucciarelli S, Ramos-Casals M, Ingelmo M,
Asherson RA, Font J; Catastrophic Antiphospholipid Syndrome
(CAPS) Registry Project Group: Intestinal involvement secondary
to the antiphospholipid syndrome (APS): Clinical and immunologic
characteristics of 97 patients: comparison of classic and catastrophic
APS. Semin. Arthritis Rheum 2007; 36: 287-296
9. Helliwell TR, Flook D, Whitworth J, Day DW: Arteritis and
venulitis in systemic lupus erythematosus resulting in massive
lower intestinal haemorrhage. Histopathology 1985; 9: 1103-1113
10. Ju JH, Min JK, Jung CK, Oh SN, Kwok SK, Kang KY, Park KS,
Ko H J, Yoon CH, Park SH, Cho SH, Kim HY: Lupus mesenteric
vasculitis can cause acute abdominal pain in patients with SLE. Nat
Rev Rheumatol 2009; 5: 273-281
11. Ginzburg L, Klein E: Late intestinal stenosis following strangulated
hernia. Ann Surg 1928; 88: 204-211
12. Drenkard C, Villa AR, Reyes E, Abello M, Alarcon-Segovia D:
Vasculitis in systemic lupus erythematosus. Lupus 1997; 6: 235-242
13. Zizic TM, Classen JN, Stevens MB: Acute abdominal complications
of systemic lupus erythematosus and polyarteritis nodosa. Am J
Med 1982; 73: 525-531
14. Medina F, Ayala A, Jara LJ, Becerra M, Miranda JM, Fraga A:
Acute abdomen in systemic lupus erythematosus: The importance
of early laparotomy. Am J Med 1997; 103: 100-105

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