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KONTRAST MADDEYE BAĞLI NEFROTOKSÎSÎTE VE TEDAVİ YAKLAŞIMLARI

CONTRAST MEDIA-ASSOCIATED NEPHROTOXICITY AND THERAPEUTIC PERSPECTIVES

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 2000

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Contrast associated nephropathy is an acute disturbance of renal function that follows the intravascular administration of radiocontrast agents. This syndrome is usually recognized one or more days following the radiocontrast agent administration and is based on an increase in serum creatinine concentration with or without associated oliguria. A variety of mechanisms have been suggested to play a role in the pathophysiology of radiocontrast agent-induced acute renal failure and include direct toxicity, hemodynamic alterations, and tubular obstruction. There is currently no spesific curative treatment for prevention of contrast media associated nephropathy. Measures include minimization of the contrast media volume, volume expansion with saline, administration of mannitol, atrial natriuretic factor, loop diuretics, calcium antagonists, theophylline or dopamine, and the use of low osmolar contrast media.
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Abstract (Original Language): 
Kontrast maddeye bağlı nefropati, radiokontrast maddenin verilmesini takiben renal fonksiyonlardaki akut bozulmayı tarif eder. Bu sendrom genellikle kontrast maddenin verilmesinden bir ya da birkaç gün sonra oluşur ve oligüriyle ya da oligürisiz seyreden artmış serum kreatinin düzeyleriyle birliktedir. Radiokontrast ajanın indüklediği akut renal yetmezliğin patofızyoloj isinde direk toksisite, hemodinamik değişiklikler ve tübüler tıkanma gibi değişik mekanizmaların rol oynadığı öne sürülmektedir. Günümüzde, bu tablonun küratif tedavisi yoktur. Kontrast madde volümünün azaltılması, şalin ile volüm genişletilmesi, mannitol, atrial natriüretik faktör, lup diüretikleri, kalsiyum antagonistleri, teofılin veya dopamin uygulaması ve düşük osmolariteli kontrast maddelerin kullanımı gibi önlemler alınabilir.
FULL TEXT (PDF): 
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  • 1
14-17
  • Turkish

REFERENCES

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