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Pediyatrik Olgulardaki Kaudal Blok Uygulamalarında Bupivakain Solüsyonuna Eklenen Klonidinin Hemodinami, Postoperatif Analjezi ve Sedasyon Üzerine Etkileri

The Effects of Caudal Clonidine Added to Bupivacain Solution on Hemodynamic, Postoperative Analgesia and Sedation

Journal Name:

  • Uludağ Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 2006

Key Words:

Keywords (Original Language):

Author NameUniversity of Author
Abstract (2. Language): 
In this prospective, randomized, double-blind study, we investigated the effects of caudal block with bupivacaine and bupivacaine plus clonidine combination on hemodynamics, sedation, and postoperative analgesia in paediatric patients who underwent inguinal herniorrhpahy or orchidopexy. The study population consisted of 50 cases aged 3 to 8. Following induction of anesthesia laryngeal mask was placed. Patients were given the lateral decubitis position and then caudal anesthesia was performed. Patients were randomly divided into two groups. Each group contained 25 patients. Group B received % 0.125 1 mlkg -1 bupivacain and Group BK received % 0.125 1 mlkg -1 bupivacain plus 1µg kg -1 clonidine. The first analgesic requirement time, perioperative analgesic requirement, pain and sedation scores, heart rates, sistolic blood pressures, respiration rates and side effects were evaluated perioperatively. The duration of caudal block was significantly longer in the BK group (p<0.05). Hypotension, bradycardia or bradypnoea requiring treatment were not observed in any patient. Sedation scores at 1 and 2 h after completion of surgery were similar between groups. In conclusion, our results suggest that caudal clonidine 1 µgkg -1 added to bupivacaine prolongs the first analgesic requirement time without any clinically significant changes in sedation and hemodynamic parameters.
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Abstract (Original Language): 
İnguinal herni ve orşiopeksi operasyonu geçirecek pediatrik olgularda, prospektif, randomize ve çift kör olarak planlanan bu çalışmada, kaudal blok için uyguladığımız bupivakain %0.125 solüsyonu ile bupivakain %0.125 solüsyonuna eklenen alfa-2 agonisti klonidinin hemodinami, postoperatif analjezi ve sedasyon üzerine etkilerini araştırdık. Çalışma 3-8 yaşları arasındaki 50 hastada planlandı. Anestezi indüksiyonu sonrası, laringeal maske yerleştirilen hastalara lateral dekübitus pozisyonunda kaudal blok uygulandı. Olgular her grupta 25 hasta olacak şekilde rastgele iki gruba ayrıldılar. Olguların yarısına (n=25) %0.125 bupivakain 1 mlkg -1 (Grup B), kalan yarısına %0.125 bupivacaine 1 mlkg -1 + klonidin 1µgkg -1 (Grup BK) verildi. Olguların ilk analjezik gereksinim zamanları, perioperatif analjezik ihtiyacı, ağrı ve sedasyon skorları, kalp hızı, sistolik kan basınçları, solunum sayıları ve yan etkiler perioperatif değerlendirildi. Her iki grup karşılaştırıldığında, BK gurubunda kaudal blok analjezi süresi anlamlı derecede uzundu. Olguların hiçbirinde klinik olarak anlamlı hemodinamik değişiklik, bradikardi ve solunum depresyonuna rastlanmadı. Grup B ve Grup BK’nın ilk 2 saatteki sedasyon skorları benzerdi (p>0.05). Sonuç olarak, kaudal analjezi için bupivakain solüsyonuna klonidin eklenmesi, hemodinami ve sedasyon derinliğinde klinik olarak anlamlı değişikliklere yol açmadan ilk analjezik gereksinim zamanını uzatmaktadır.
FULL TEXT (PDF): 
PDF icon arastirmax-pediyatrik-olgulardaki-kaudal-blok-uygulamalarinda-bupivakain-solusyonuna-eklenen-klonidinin-hemodinami-postoperatif-analjezi-sedasyon-uzerine-etkileri.pdf
  • 3
71-75
  • Turkish

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