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İNTRAUTERİN GELİŞME GERİLİĞİ OLGULARINDA UTERİN ARTER DOPPLER BULGULARININ PLASENTA YATAK BİYOPSİSİ HİSTOLOJİSİ İLE İLİŞKİSİ

Journal Name:

  • Cerrahpaşa Tıp Dergisi

Publication Year:

  • 2002

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
The aim of this study was to determine the relationship between placental bed biopsy findings and uterine artery doppler flow parameters in intrauterine growth retardation(IUGR). We tested the hypotesis that Doppler velocimetry of the uterine artery in cases of fetal intrauterine growth retardation can reflect the presence of vascular maladaptation to pregnancy. Uterine artery doppler velocimetry was obtained in 47 consecutive pregnancies with IUGR and 26 unevetful control pregnancies. Abnormal uterine doppler velocimetry was defined as an average of S/D ratio>2.6 and distolic notching. In cases of C/S, after removal of the placenta, a placental bed biopsy, containing the uteroplacental vessels of the decidual and inner myometrial layer, was taken. The bed biopsies were examined for uteroplacental vascular pathological features. Results.- The physiological changes in the spiral arteries was seen in all (100%) AGA fetuses, in 45% of IUGG cases. The pathologicall changes in the placental bed biopsy was found %0 for controls, % 16 for growthrestricted fetuses with normal uterine artery Doppler, and % 82 for IUGR fetuses with abnormal uterine artery Doppler. Conclusion.- These data suggest that Doppler velocimetry of the uterine arteries is predictive of vascular lesions in growth-restricted fetuses.
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Abstract (Original Language): 
Çalışmanın amacı, intrauterin gelişme geriliği olgularında plasenta yatak biyopsisi histolojisinin uterin arter doppler bulgularıyla ilişkisini incelemek ve patolojik Doppler bulgularına dayanarak plasentasyondaki bozukluğun önceden belirlenip belirlenemeyeceğini araştırmakt ır. Cerrahpaşa Tıp Fakültesi Kadın Hastalıkları ve Doğum Anabilim Dalı’na başvuran ve gerekli tetkikler sonrası intrauterin gelişme geriliği tanısı koyulan 47 hasta ve fetal gelişimin normal olarak saptandığı 26 kontrol olgusu çal ışmaya dahil edildi. Hastalara doğumdan önceki 3 gün içinde Doppler USG yapıldı. Uterin arter ortalama S/D oranının >2,6 olması ve diyastolik çentik bulunması anormal olarak kabul edildi. Sezaryen olan hastalardan plasenta ve zarlar ayrıldıktan sonra plasental yatak biyopsisi alındı. Plasental yatak biyopsileri histopatolojik olarak incelenerek uteroplasental vask üler patolojiler değerlendirildi. Fetal gelişimi normal olan olguların tümünde (%100), İUGG olgularının %45’inde plasental yatak biyopsisinde fizyolojik değişiklikler saptandı. Kontrol, normal uterin arter Doppler ve patolojik uterin arter Doppler bulgusu olan İUGG olgularının sırasıyla %0, %16 ve %82’sinin plasenta yatak biyopsilerinde patolojik değişimler saptandı. Çalışmamızda uterin arter Dopplerinde çentiklenme ve/veya S/D oranında yükselme ile plasental yatak biyopsisindeki patolojik bulgular arasında yakın ilişki olduğunu gördük. Bulgularımız, intrauterin gelişme geriliğinde, plasentasyondaki bozuklukların uterin arter Dopplerindeki patolojilere dayanılarak, antenatal olarak belirlenebileceğini göstermektedir.
FULL TEXT (PDF): 
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  • 4
231-235
  • Turkish

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