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Yüksek basınçlı sıvı kromatografi (HPLC) tekniği ile HbA1c ölçümünde HbF’in interferansı: olgu sunumu

Interference of HbF in HbA1c measurement by high performance liquid chromatography method: a case report

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Abstract (2. Language): 
Hemoglobin A1c (HbA1c) measurements are widely used in the monitoring of blood glucose levels in patients with diabetes mellitus. Different methods are used in the measurement of HbA1c. It is possible to obtain false results in HbA1c measurement because of the effect of different interferences. In this article, an interference which occured during measurement of HbA1c using high pressure liquid chromatography in blood sample belonging to a baby was emphasized.
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Abstract (Original Language): 
Diyabetes mellituslu hastaların kan glikoz düzeyinin izlenmesinde, hemoglobin A1c (HbA1c) ölçümleri yaygın olarak kullanılmaktadır. HbA1c ölçümünde değişik yöntemler kullanılmaktadır. HbA1c ölçümlerinde farklı interferanslar nedeniyle yanlış sonuçlar elde edilebilmektedir. Bu makalede, bir bebeğe ait kan örneğinde, yüksek basınçlı sıvı kromatografi tekniğiyle yapılan HbA1c ölçümü esnasında meydana gelen interferansa dikkat çekilmek istenmiştir.
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  • 3
211-213
  • Turkish

REFERENCES

References: 

1. Jeppsson JO, Kobold U, Barr J, et al. Approved IFCC
reference method for the measurement of HbA1c in
human blood. Clin Chem Lab Med 2002; 40: 78-89.
2. Goldstein D, Little R, Lorenz RA, et al. Tests of glycemia
in diabetes. Diabetes Care 2004; 27: 1761-1773.
3. Thevarajah M, Nadzimah MN, Chew YY. Interference
of hemoglobin A1c (HbA1c) detection using ionexchange high performance liquid chromatography
(HPLC) method by clinically silent hemoglobin variant
in University Malaya Medical Centre (UMMC)--a case
report. Clin Biochem 2009; 42: 430-434.
4. Fairbanks VF, Klee GG. Biochemical aspects of
hematology. In: Burtis CA, Ashwood ER (eds). Tietz
Textbook of Clinical Chemistry. 3rd ed. Philadelphia:
WB Saunders, 1999: 1642-1710.
5. Weykamp CW, Penders TJ, Muskiet FA, van der Slik W.
Influence of hemoglobin variants and derivatives on
glycohemoglobin determinations, as investigated by
102 laboratories using 16 methods. Clin Chem 1993;
39: 1717-1723.
6. Bry L, Chen PC, Sacks DB. Effects of hemoglobin
variants and chemically modified derivatives on assays
for glycohemoglobin. Clin Chem 2001; 47: 153-163.
7. Schnedl WJ, Krause R, Halwachs-Baumann G, Trinker M,
Lipp RW, Krejs GJ. Evaluation of HbA1c determination
methods in patients with hemoglobinopathies. Diabetes
Care 2000; 23: 339-344.

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